Texaphyrin metal complex mediated ester hydrolysis

Details Texaphyrin metal complex mediated ester hydrolysis Texaphyrin metal complex mediated ester hydrolysis

1994-04-14

1996-09-24

Patterson, Jr., Charles L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

5303871, 536 111, 536 231, 435 911, 435135, 435155, 534 11, 534 15, 534 16, C07K 200, C07K 1600, C07H 300, C07F 500

Patent

active

055592074

ABSTRACT:
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.

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