Tetrapeptide

Details Tetrapeptide Tetrapeptide

1983-11-22

1986-03-25

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 1, 623 66, 2601125R, 128 1R, 128334R, 424177, A61F 100, A61K 3700, C07C10352, C07G 700

Patent

active

045780790

ABSTRACT:
The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.

REFERENCES:
Seitz et al., "Effect of Fibronectin . . . "; J. of Biomed. Mat. Res.; vol. 16 #3; pp. 195-207; 5/1982.
Hynes, et al., Cell Surface Fibronectin and Oncogenic Transformation, J. Supramolecular Structure 11:95-104 (1979).
Hahn, Lian-Hsien E. and Kenneth M. Yamada, Isolation and Biological Characterization of Active Fragments of the Adhesive Glycoprotein Fibronectin, Cell18:1043-1051, 1979.
Sekiguchi, Kiyotoshi and Sen-Itiroh Hakomori, Functional Domain Structure of Fibronectin, Proc. Natl. Acad. Sci. 77:2661-2665, 1980.
Grinnell, Frederick, et al., Distribution of Fibronectin During Wound Healing in Vivo. J. Invest. Dermatol. 76:181-189, 1981.
McDonagh, R. P., et al., Amino Acid Sequence of the Factor XIII.sub.a Acceptor Site in Bovine Plasma Fibronectin, Febs Letters 127:174-178, 1981.
Ruoslahti, Erkki, et al., Alignment of Biologically Active Domains in the Fibronectin Molecule, J. Biol. Chem. 256:7277-2781, 1981.
Pande, Hema, et al., Comparative Structural Studies of Human Plasma and Amniotic Fluid Fibronectins, Bioch. Biophy. Res. Comm. 101:265-272, 1981.
Pande, Hema and John E. Shively, NH.sub.2 -Terminal Sequences of DNA-, Heparin-, and Gelatin-Binding Tryptic Fragments from Human Plasma Fibronectin, Arch. Bioch. Biophy. 213:258-265, 1982.
Pierschbacher, Michael D., et al., The Cell Attachment Domain of Fibronectin, J. Biol. Chem. 257:9593-9597, 1982.
Vibe-Pedersen, Karen, et al., Amino Acid Sequence of a Peptide from Bovine Plasma Fibronectin Containing a Free Sulfhydryl Group (Cysteine) Febs. Letters 142:26-30, 1982.
Sekiguchi, Kiyotoshi, et al., Monoclonal Antibodies Directed to Two Different Domains of Human Plasma Fibronectin: Their Specificities, Fed. Eur. Bich. Soc. 142:243-246, 1982.
Ehrismann, Ruth, et al., Arrangement of Attachment-Promoting, Self-Association, and Heparin-Binding Sites in Horse Serum Fibronectin, J. Biol. Chem. 257:7381-7387, 1982.
Clark, Richard A. F., et al., Fibronectin is Produced by Blood Vessels in Response to Injury, J. Exp. Med. 156:646-651, 1982.
Hynes, Richard O. and Kenneth M. Yamada, Fibronectins: Multifunctional Modular Glycoproteins, J. Cell. Biol. 95:369-377, 1982.
Petersen, Torbene, et al., Partial Primary Structure of Bovine Plasma Fibronectin: Three Types of Internal Homology, Proc. Natl. Acad. Sci. 80:137-141, 1983.
Grinnell, Frederick, Cell Attachment and Spreading Factors in Growth and Maturation Factors (Dr. Gordon Guroff, Ed.) John Wiley & Sons, Inc., 1983.
Hayashi, Masao and Kenneth M. Yamada, Domain Structure of the Carboxyl-Terminal Half of Human Plasma Fibronectin, J. Biol. Chem. 258:3332-3340, 1983.
Kornblihtt, Alberto R., et al., Isolation and Characterization of cDNA Clones for Human and Bovine Fibronectins, Proc. Natl. Acad. Sci. 80:3218-3222, 1983.
Pierschbacher, Michael, et al., Synthetic Peptide With Cell Attachment Activity of Fibronectin, Proc. Natl. Acad. Sci. 80:1224-1227, 1983.

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