Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs t

Details Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs t Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs t

1993-12-01

1995-07-25

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 65, A61K 31535, C07D27301

Patent

active

054362423

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.

REFERENCES:
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patent: 4127580 (1978-11-01), Braye
patent: 4136186 (1979-01-01), Frehel et al.
patent: 4458074 (1984-07-01), Bouscuet et al.
patent: 4464377 (1984-08-01), Blanchard et al.
patent: 4529596 (1985-07-01), Aubert et al.
patent: 4740510 (1988-04-01), Badorc et al.

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