Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-12-07
1989-08-22
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514323, 514397, 540603, 546200, 548336, A61K 3155, A61K 31415, C07D40306
Patent
active
048596620
ABSTRACT:
The invention relates to compounds of the general formula (I): ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
REFERENCES:
patent: 3634420 (1972-01-01), Littell et al.
patent: 3740404 (1973-06-01), Littell et al.
patent: 4695578 (1987-09-01), Coates et al.
patent: 4725615 (1988-02-01), Coates et al.
patent: 4749718 (1988-06-01), Coates et al.
R. Littell et al., J. Med. Chem., 1972, 15(8), 875-876.
Bell James A.
Bradshaw John
Coates Ian H.
Ewan George B.
Humber David C.
Glaxo Group Limited
Schwartz Richard A.
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