Tetrahydro carbazolone intermediates

Details Tetrahydro carbazolone intermediates Tetrahydro carbazolone intermediates

1987-11-27

1989-04-18

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546200, 548336, C07D40306

Patent

active

048228818

ABSTRACT:
The invention relates to compounds of the general formula (I): ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.

REFERENCES:
patent: 3634420 (1972-01-01), Littell et al.
patent: 3740404 (1973-06-01), Littell et al.
patent: 4695578 (1987-09-01), Coates et al.
patent: 4725615 (1988-02-01), Coates et al.
patent: 4739072 (1988-04-01), Oxford et al.
patent: 4749718 (1988-06-01), Coates et al.
R. Littell et al., J. Med. Chem., 1972, 15(8), 875-876.

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