Tetrafluorobenzyl derivatives and pharmaceutical composition...

Details Tetrafluorobenzyl derivatives and pharmaceutical composition... Tetrafluorobenzyl derivatives and pharmaceutical composition...

2008-01-15

2008-01-15

Puttlitz, Karl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C514S535000

Reexamination Certificate

active

11603653

ABSTRACT:
The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl derivative of the present invention can effectively be used to prevent and treat chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, degenerative brain disease such as epilepsy and ischemic brain disease such as stroke.

REFERENCES:
patent: 3632760 (1972-01-01), Shen et al.
patent: 3674844 (1972-07-01), Shen et al.
patent: 5434163 (1995-07-01), Edlind et al.
patent: 5527814 (1996-06-01), Louvel
patent: 6136835 (2000-10-01), Camden
patent: 6358945 (2002-03-01), Breitfelder et al.
patent: 6927303 (2005-08-01), Gwag et al.
patent: 2005/0239896 (2005-10-01), Gwag et al.
patent: 2006/0135600 (2006-06-01), Gwag et al.
patent: 2031227 (1971-01-01), None
patent: 122827 (1984-10-01), None
patent: 1268465 (1972-03-01), None
patent: 54-125632 (1979-09-01), None
patent: 60-237041 (1985-11-01), None
patent: 2000-212141 (2000-08-01), None
patent: 2000-273041 (2000-10-01), None
patent: WO86/03199 (1986-06-01), None
patent: WO94/13663 (1994-06-01), None
patent: WO99/01421 (1999-01-01), None
Anderson, D.K. et al., Ann. Emerg. Med. 22:987-992 (1993).
Anderson, W.W. et al., J. Neurophysiol. 57:1-21 (1987).
Beal, M.F. et al, J.Neurosci. 11:1649-1659 (1991).
Beal, M.F. et al., Nature 321: 168-171 (1986).
Beal, M.F., Ann. Neurol. 38:357-366 (1995).
Benveniste, H et al.,J Neurochem, 43(5):1369-1374 (1984).
Brouillet, E. et al., Neuroreport. 4:387-390 (1993).
Browne, S.E. et al., Brain Pathol. 9:147-163 (1999).
Bush, A.I. et al., Science 265:1464-1467 (1994).
Chan, P. H.J. Neurotrauma., 9 Suppl 2:S417-423 (1992).
Chan, P.H., Stroke 27:1124-1129 (1996).
Choi, D.W. et al., J Neurosci. 7:369-379, 1987.
Choi, D.W. et al., Annu Rev Neurosci 13:171-182 (1990).
Choi, D.W. et al., Annu. Rev. Neursci 21:347-375 (1988).
Choi, D.W. et al., Journal of Neuroscience 7(2): 357-368 (1987).
Choi, D.W., Neuron 1:623-634 (1988).
Cuajungco, M.P. et al., Brain Research Reviews 23:219-236 (1997).
Demediuk, P. et al., J Neurochem. 52:1529-1536 (1989).
Dexter, D. T. et al.,Ann Neurol., 32 Suppl:S94-100 (1992).
Dingledine, R. et al., Trends Pharmacol. Sci. 11:334-338 (1990).
Eisen, A. et al., Drugs Aging 14:173-196 (1999).
Faden, A.I. et al, Science 244:798-800 (1989).
Faden, A.I. et al., J. Neurotrauma. 5:33-45 (1988).
Faden, A.I., Pharmacol. Toxicol. 78:12-17 (1996).
Fahn, S. and Cohen, G.,Ann. Neurol., 32(6):804-812 (1992).
Ferrante, R. J. et al.,Science, 230(4625):561-563 (1985).
Fischer-Nielsen, A. et al.,Free Radic Biol Med. 13(2): 121-126 (1992).
Flamm, E. S. et al.,Stroke, 9(5):445-447 (1978).
Frederickson, C. J. and Bush, A. I.,Biometals, 14:353-366 (2001).
Frederickson, C.J. et al., Brain Res. 480:317-321 (1989).
Gerlach, M. et al.,Journal of Neurochemistry63: 793-807 (1994).
Gilgun-Sherki, Y. et al.,Pharmacological Reviews54: 271-284 (2002).
Goldberg, M. P. et al.J. Pharmac. Exp. Ther., 243:784-791 (1987).
Goldberg, M.P. et al., J Neurosci. 13:3510-3524 (1993).
Goodman & Gilman's The Pharmacological Basis of Therapeutics, Joel G. Hardman et al., eds., 9.sup.th edition, 1996, The McGraw-Hill Companies, pp. 617-631 & 1059-1062.
Grisham, M.B. et al.,Dig. Dis Sci. 37(9): 1383-1389 (1992).
Grundman, M., Am.J.Clin.Nutr. 71:630S-636S (2000).
Gwag, BJ et al., Neuroscience. 68:615-619 (1995).
Hall, E.D. et al., Free Radic.Biol.Med. 6:303-313 (1989).
Hall, E.D. et al., J. of Neurotrauma. 5:81-89 (1988).
Hall, E.D., Neurosurg.Clin.N.Am. 8:195-206 (1997).
Holmes, G.L. et al., Cleve. Clin. J. Med. 62:240-247 (1995).
Hussain, F.N. et al.,Br J. Clin Pharmacol. 49(4): 323-330, Apr. (2000).
Ikonomidou, C, et al., J. Neuropathol. Exp. Neurol. 55:211-224 (1996).
International Preliminary Examination Report for PCT/KR 00/00366, Aug. 23, 2002.
Jenner, and Olanow, Neurology 47:S161-S170 (1996).
Jenner, P., Pathol. Biol. (Paris.) 44:57-64 (1996).
Joo, C-K. et al, Investigative Ophthalmology & Visual Science 40:713-720 (1999).
Kass, I.S. et al., Exp. Neurol. 103:116-122 (1989).
Kim, E.Y. et al, European Journal of Neuroscience, 11:327-334 (1999).
Klotz et al.,Arzneimittel-Forschung. Drug Research43(12): 1357-1359, Dec. (1993).
Kogure, K. et al.,Prog. Brain Res. 63:237-259 (1985).
Koh, J.Y. et al., J Neurosci Methods 20:83-90 (1987).
Koh, J.Y. et al., Science 234:73-76 (1986).
Koh, J.Y. et al., Science 272: 1013-1016 (1996).
Kumamoto, T. et al.,Jpn. J. Pharmacol. 75: 187-189, 1997.
Ikonomidou, C, et al., J. Neuropathol. Exp. Neurol. 55:211-224 (1996).
Lakowski, B. et al., Science 272: 1010-1013 (1996).
Lange, K.W. et al., Naunyn Schmiedebergs Arch.Pharmacol. 348(6):586-592 (1993).
Lee et al.,Proc. Natl. Acad. Sci., U.S.A. 99:7705-7710 (2002).
Lee, J-M et al., Nature 399:A7-A14 (1999).
Lehninger et al., Principles of Biochemistry, 2nd. ed. 384-390, 1993.
Love, S., Brain Pathol. 9:119-131 (1999).
Marin, C. et al., Brain Res. 736:202-205 (1996).
McNamara, J.O. et al., Neuropharmacology 27:563-568 (1988).
Merello, M. et al., Clin. Neuropharmacol. 22:273-276 (1999).
Metman, L.V. et al., Neurology 51:203-206 (1998).
Minta, A. et al., Journal of Biological Chemistry 264(14):8171-8178 (1989).
Montastruc, J.L. et al, Neuroscience and Biobehavioral Reviews 21(4):477-480 (1997).
Mysyk, D. D. et al., “Chloromethylation of 4-arenesulfonyl-N-methylamidoanisoles,” Soviet Progress in Chemistry. 33(2), 59-62 (1967).
Nussbaumer, P. et al., “Novel Antiproliferative Agents Derived from Lavendustin A,” J. Med. Chem. 37(24), 4079-84 (1994).
Okiyama, K. et al., J. Neurotrauma. 14:211-222 (1997).
Olney et al.,Science, 244:1360-1362 (1989).
Olney, J. W. and Ho, O. L.,Nature, 227(258): 609-611 (1970).
Olney, J. W. and Sharpe, L. G.,Science, 166:386-388 (1969).
Olney, J. W.Int Rev. Neurobiol., 27:337-362 (1985).
Papa, S.M. et al., Ann. Neurol. 39:574-578 (1996).
Park, C,K, et al., Ann Neurol. 24:543-551 (1988).
PCT International Search Report, PCT/KR00-00366.
Prasad, K.N. et al., J. Am. Coll. Nutr. 18:413-423 (1999).
Rizzi, E. et al., “Electron Impact Spectrometry of some 5-amin-osalicylic acid derivatives,” Rapid Commun. Mass Spectrom. 1994, 8(2), 158-62.
Rosen, D.R. et al., Nature 362:59-62 (1993).
Rothstein, J.D. et al., Clin. Neurosci. 3:348-359 (1995).
Schapira, A. H.,Curr. Opin. Neurol., 9(4)260-264 (1996).
Schröder, H. et al., Clin. Pharmacol. Ther. 13:539-551 (1972).
Schubert, D. et al.,Proc. Natl. Acad. Sci., U.S.A. 92(6):1989-1993 (1995).
Shaw, P. J. and Ince, P. G.,J. Neurol.. 244 Suppl 2:S3-14 (1997).
Sheardown, M. J. et al,Science, 247:571-574 (1990).
Siegel G. J. et al.,Basic Neurochemistry, 6thedition, Lippincott Williams & Wilkins, 315-333 (1999).
Siesjö, B.K. et al., Eur. J. Anaesthesiol. 13:247-268 (1996).
Simon, R.P. et al., Science 226:850-852 (1984).
Sinz, E.H. et al, J. of Cerebral Blood Flow and Metabolism 18:610-615 (1998).
Smith, M.A., et al., Proc. Natl. Acad. Sci. U.S.A. 94:9866-9868 (1997).
Smith, P.R. et al., Gut 20:802-805 (1979).
Sofic, E. et al.,J. Neurol Transm., 74:199-205 (1988).
Spector, R. et al.,J. Pharmacol. Exp. Ther. 188: 55-65 (1974).
Stenson, W.F. et al., J Clin. Invest. 69, 494-497 (1982).
Suh, S.W. et al., Brain Res. 852 268-273 (2000).
Suh, S.W. et al., Brain Res. 852:274-278 (2000).
Wahl, C. et al.; J. Clin.Invest. 101:1163-1174 (1998).
Webster's II, New Riverside University Dictionary, Riverside Publishing Company, p. 933, 1988.
Weiss et al.,Trend Pharmacol., Sci.21:395-401 (2001).
Weiss, J. et al., Brain Res. 380:186-190 (1986).
Weiss, J.H. et al., Neuron. 10:43-49 (1993).
Wieloch, T., Science 230:681-683 (1985).
Won, S.J. et al., Neurobiology of Disease 7:251-2599 (20000.
Wong, B.Y. et al., Neurosci.Lett. 85:261-266 (1988).
Zeidman, S.M. et al., J. Spinal. Disord. 9:367-380 (1996).

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