Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2008-09-16
2010-10-12
Hill, Kevin K. (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C514S04400A
Reexamination Certificate
active
07811814
ABSTRACT:
A vector and a method are provided for delivering a nucleic acid to a nervous system cell. The vector includes a first nucleic acid, a second nucleic acid, inverted terminal repeats of adeno-associated virus, and a tetracycline-off regulatable promoter system that includes a first promoter operably linked to the first nucleic acid and a second promoter operably linked to the second nucleic acid. The promoters drive expression in opposite directions and away from the inverted terminal repeats. The method includes providing a recombinant adeno-associated viral (rAAV) vector and administering the vector to a nervous system cell. Expression of a product from the first nucleic acid is regulatable by the promoter system.
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Bohn Martha C.
Jiang Lixin
Vanin Elio F.
West Neva C.
Brinks Hofer Gilson & Lione
Children's Memorial Hospital
Hill Kevin K.
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