Terpenoid compound 0406TP-1

Details Terpenoid compound 0406TP-1 Terpenoid compound 0406TP-1

1998-01-22

1999-08-03

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 74, 435 78, 514 53, 536 41, 536 179, 536 181, C12P 1935, A61K 3171, C07M 1500

Patent

active

059325550

ABSTRACT:
The present invention relates to compound 0406TP-1 represented by the general formula (I): ##STR1## wherein Ac represents an acetyl group and Me represents a methyl group, or a pharmaceutically acceptable salt thereof, having excellent antitumor activity and immunosuppressive activity.

REFERENCES:
Kino, Toru et al., "FK-506, a novel immunosuppressant isolated from a streptomyces.", The Journal of Antibiotics, vol. XL, No. 9, pp. 1249-1255 (1987).
Borel, J.F. et al., "Biological effects of cyclosporin A: a new antilymphocytic agent.", Agents and Action, vol. 6, No. 4, pp. 468-475 (1976).
Mikami, Yuzuru et al., "Susceptibility patterns of pathogenic nocardia to some selected antimicrobial agents and their usefulness in the identification work in a clinical laboratory.", JFCC, vol. 5, pp. 89-95 (1989).
Hatanaka, Hiroshi et al., "FR-900520 and FR-900523, novel immunosuppressants isolated from a streptomyces.", The Journal of Antibiotics, vol. XLI, No. 11, pp. 1592-1601 (1988).
Fujita, Tetsuro et al., "Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.", The Journal of Antibiotics, vol. 47, No. 2, pp. 208-215 (1994).

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