Temporary inactivation of serine hydrolases using nitrophenyl ph

Details Temporary inactivation of serine hydrolases using nitrophenyl ph Temporary inactivation of serine hydrolases using nitrophenyl ph

1992-03-04

1994-01-25

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435183, 435188, C12N 999, C12N 900, C12N 996

Patent

active

052815234

ABSTRACT:
Phenacyl phosphonate adducts of serine hydrolases temporarily inactivate the hydrolases. The hydrolases are reactivated by intramolecularly catalyzed dephosphonylation of the adduct over a period of time. Half-lives for dephosphonylation in the range of about 30 to 500 minutes have been observed at physiological pH's.

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