Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-05-12
2000-08-22
Carlson, Karen Cochrane
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 530300, C07K 100
Patent
active
061074632
ABSTRACT:
Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
REFERENCES:
patent: 5606022 (1997-02-01), Rasmussen
Gene 123(1) 99-103 (1993) The use of degenerate, sensor gene-specific, oligodeoxyribonucleotide primers to amplify DNA fragments from Staphylococcus aureus K. W. Bayles.
Biochemistry 32(9): 11741-11753 Structural conservation in the Che Y superfamily K. Volz.
Journal of Bacteriology 170(11): 5093-5101 Deduced Polypeptides Encoded by the Bacillus subtilis sacU Locus Share Homology with Two-Component Sensor-Regulator Systems Frank Kunst et al.
Hodgson John Edward
Wallis Nicola Gail
Carlson Karen Cochrane
Deibert Thomas S.
Gimmi Edward R.
King William T.
SmithKline Beecham Corporation
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