Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-05-02
2006-05-02
Lambkin, Deborah C. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S449000, C564S074000, C549S510000
Reexamination Certificate
active
07037940
ABSTRACT:
Disclosed is a compound represented by the Structural Formula (I):Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—.R1and R2are independently an aryl group or a substituted aryl group, R3and R4are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R5–R6are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R7and R8are each independently —H, an aliphatic or substituted aliphatic group, or R7is —H and R8is a substituted or unsubstituted aryl group, or, R7and R8, taken together, are a C2–C6 substituted or unsubstituted alkylene group.Z is ═0 or ═S.Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.
REFERENCES:
patent: 4012360 (1977-03-01), Schwarzenbach et al.
patent: 6013836 (2000-01-01), Hsu et al.
patent: 6172108 (2001-01-01), Vega et al.
patent: 6172188 (2001-01-01), Thastrup et al.
patent: 6235787 (2001-05-01), Broadhurst et al.
patent: 6365745 (2002-04-01), Matsui et al.
patent: 6399659 (2002-06-01), Usui et al.
patent: 6435787 (2002-08-01), John
patent: 6455515 (2002-09-01), Gypser et al.
patent: 6656971 (2003-12-01), Wu et al.
patent: 6703426 (2004-03-01), Miles et al.
patent: 6762204 (2004-07-01), Koya et al.
patent: 6800660 (2004-10-01), Koya et al.
patent: 6825235 (2004-11-01), Chen et al.
patent: 2003/0045518 (2003-03-01), Koya et al.
patent: 2003/0119914 (2003-06-01), Koya et al.
patent: 2003/0195258 (2003-10-01), Koya et al.
patent: 2037257 (1972-02-01), None
patent: 2097737 (1972-04-01), None
patent: WO 94/10995 (1994-05-01), None
patent: WO 99/34796 (1999-07-01), None
patent: WO 03/006428 (2003-01-01), None
patent: WO 03/006430 (2003-01-01), None
Barry, V. C., et al., “Anticancer Agents-III. Synthesis and Anticancer Activity of Some Bis-Thiosemicarbazones and Thoiosemicarbazides,”Proc. R.I.A. 65:309-324 1967).
O'Callaghan, C. N., “Anticancer Agents-X. Cyclisation of 1-Acyl-4-Alkylthiosemicarbazide Derivatives to 1,2,4-Triazoline-3-Thiones in the Presence of Hydrazine,”Proc. R.I.A. 74:455-461 (1974).
Chuyguk, V. A. and Nemazanyj A.G., “Mesoionic Methine Dyes from Biquaternary Salts of Dihetarylmethanes—1,3,4-Oxa(thia)diazoles and 1,2,4-Triazoles Derivatives,”Ukr. Khim. Zhurn. 48:520 (1984).
“REMARKS” paper as submitted by applicant's attorney.
Stalteri, M.A., et al., “Site-specific conjugation and labelling of prostate antibody 7E11C5.3 (CYT-351) with technetium-99m,”European Journal of Nuclear Medicine24(6):651-654, (1997).
Twomey, D., “Anticancer Agents-IX. Derivatives of Pyridine, Pyridazine and Phthalazine,”Proceedings of the Royal Irish Academy, vol. 74, Sect. B:37-52,(1974).
Schwarz et al., CA77:48081, 1972.
Rupp, Walter, CA76:126992, 1972.
Chen Shoujun
Koya Keizo
Ono Mitsunori
Sun Lijun
Tatsuta Noriaki
Hamilton Brook Smith & Reynolds P.C.
Lambkin Deborah C.
Synta Pharmaceuticals Corp.
LandOfFree
Taxol enhancer compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Taxol enhancer compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Taxol enhancer compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3620694