Taxane derivatives and processes for the preparation thereof

Details Taxane derivatives and processes for the preparation thereof Taxane derivatives and processes for the preparation thereof

2005-06-14

2005-06-14

Saeed, Kamal (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S432000

Reexamination Certificate

active

06906101

ABSTRACT:
A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-β-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.

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G. Appendino et al., “Synthesis and Evaluation of C-seco-Paclitaxel Analogues”, Tetrahedron Letters, vol. 38, No. 24, 1997, pp. 4273-4276.
I. Ojiwa et al., “Synthesis and Structure-Activity Relationships of Taxoids Derived From 14-beta-Hydroxy-10-deacetylbaccatin III”,Journal of Chemistry, vol. 40, No. 2, Jan. 17, 1997, pp. 267-278.

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