Tartrate salts of 5,8,14-triazatetracyclo[10.3.1.0 2,11 .0...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S343000

Reexamination Certificate

active

11069724

ABSTRACT:
The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene:and pharmaceutical compositions thereof. The present invention in particular is directed to the L-tartrate salt, and further to the various polymorphs of the L-tartrate salt, including two distinct anhydrous polymorphs (referred to herein as Forms A and B) and a hydrate polymorph (referred to herein as Form C). In addition, the present invention is also directed to the D-tartrate salt of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene and the various polymorphs thereof; as well as the D,L-tartrate salt thereof and its polymorphs, and the meso-tartrate salt thereof and its polymorphs.

REFERENCES:
patent: 3471503 (1969-10-01), Carson
patent: 1078637 (2001-02-01), None
patent: WO 9935131 (1999-07-01), None
Paul H. Mazzochi, et al., “Synthesis and Pharmacological Activity of 2,3,4,5-Tetrahydro-1,5-Methano-1H-3-Benzazepines”, J. Med. Chem., vol. 22, No. 4, 1979, pp. 455-457, XP002090422.

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