Tamoxifen as a therapy to reduce irinotecan hydrochloride-induce

Details Tamoxifen as a therapy to reduce irinotecan hydrochloride-induce Tamoxifen as a therapy to reduce irinotecan hydrochloride-induce

1999-06-10

2000-07-11

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514648, A61K 31445, A61K 31135

Patent

active

060873779

ABSTRACT:
The present invention provides a method for preventing or decreasing diarrhea associated with irinotecan administration comprising the administration of tamoxifen at least two cell cycles prior to irinotecan administration.

REFERENCES:
patent: 4536516 (1985-08-01), Harper et al.
patent: 4604463 (1986-08-01), Miyasaka et al.
Jaiyesimi, IA, et al.; Use of Tomoxifen for Breast Cancer: Twenty-Eight Years Later, J. Clin. Oncol. 13:513-529, 1995.
Gould, K., et al.; Breast Cancer Prevention: A Summary of the Chemoprevention Trial with Tomoxifen, Oncol. Nurs. Forum. 21:835-840, 1994.
Otto, AM., et al.; Cell-cycle Arrest, Micronucleus Formation, and Cell Death in Growth Inhibition of MCF-7 Breast Cancer Cells by Tamoxifen and Cisplatin, J. Cancer Res. Clin. Oncol. 122:603-612, 1996.
Watts, CKW., et al.; Antiestrogen Inhibition of Cell Cycle Progression in Breast Cancer Cells is Associated with Inhibition of Cyclin-Dependent Kinase Activity and Decreased Retinoblastoma Protein Phosphorylation, Mol. Endocrin. 9:1804-1813, 1995.

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