Tacrine and cytochrome P450 oxidase inhibitors and methods of us

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514400, 514406, 514256, 514255, 514247, 514365, 514374, 514394, 514393, A61K 3144, A61K 31415, A61K 31505, A61K 31495

Patent

active

054666961

ABSTRACT:
Described is a method of treating Alzheimer's disease in a patient comprising administering to said patient an effective amount of tacrine in combination with a P450 1A2 oxidase inhibitor. Preferably, the inhibitor is a heterocyclic guanidine.

REFERENCES:
patent: 2233970 (1941-03-01), Andersag et al.
patent: 3659019 (1972-04-01), Koppe et al.
patent: 3950333 (1976-04-01), Durant et al.
patent: 4352803 (1982-10-01), Matsumoto et al.
patent: 4359578 (1982-11-01), Matsumoto et al.
patent: 4442101 (1984-04-01), Ichibashi
patent: 4631286 (1986-12-01), Schutske et al.
patent: 4695573 (1987-09-01), Schutske et al.
patent: 4754050 (1988-06-01), Schutske et al.
patent: 4816456 (1989-03-01), Summers
patent: 4835275 (1989-05-01), Schutske et al.
patent: 4839364 (1989-06-01), Schutske et al.
patent: 4999430 (1991-03-01), Kester et al.
patent: 5019395 (1991-05-01), Mahjour et al.
"An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro studies with human liver microsomes", Madden et al, Proceedings of the BPS, 14-16 Apr. 1993, British Journal of Clinical Pharmacology, vol. 36, No. 2, Aug. 1993.
"An Investigation into the Formation Of Stable, Protein-Reactive and Cytotoxic Metabolites From Tacrine In Virto, Studies With Human And Rat Liver Microsomes", Madden et al, Dept. of Pharmacology and Therapeutics, University of Liverpool, Biochemical Pharmacology, vol. 46, No. 1, pp. 13-20, 1993.
"The effet of Buthionine sulphoximine, cimetidine and phenobarbitone on the disposition of amsacrine in the rabbit", J. W. Paxton et al, Cancer Chemotherapy and Pharmacology, 1986, 18:208-212.
"Hepatotoxicity of Tetrahydroaminoacridine in Isolated Rat Hepatocytes: Effect of Gluta-Thione and Vitamin E", Peter Dogterom et al, Biochemical Pharmacology, vol. 37, No. 12, pp. 2311-2313, 1988.
"Cytochromes P-450 in Rats: structures, functions, properties and relevant human forms" P. Souck and I, Gut, Xenobiotica, 1992, vol. 22, No. 1, 83-103.
"Pharmacokinetic Interactions of Cimetidine 1987" Andrew Somogyl and Murray Muirhead Clinical Pharmacokinetics 12: pp. 321-366 (1987).
Chemical Abstracts, vol. 63, 1965 Columbis, Ohio,. Abstract #38 pp. 11537-11538.
Chemical Abstracts, 1961 Columbus, Ohio, Abstract #10G pp. 23501-23502.
Biochemistry, third edition. Lubert Stryer, Stanford University, W. H. Freeman and Company, New York, pp. 566-568. (1988).
"Tacrine in the Treatment of Alzheimer's Disease: A Clinical Update and Recent Pharmacologic Studies", Eur. Neurol, William K. Summers, Ken H. Tachiki, Arthur Kling, 1989:29(suppl. 3):28-32.
"Pharmacological Significance of Acetylcholinesterase Inhibition by Tetrahydroamino-Acridine", Judith K. Marquis, Biochemical Pharmacology, vol. 40, No. 5, pp. 1071-1076, 1990.
"Heterogeneity of Hepatic Adverse Reactions to Tetrahydroaminoacridine", Roberts S K, Gibson P R, Bhathal P S, Ames D J, Davies B, Fraser J R E, Aust N Z Med 20 (Suppl 1): 361, 1990-Jun.
"Drug Metabolism in Drug-Induced Liver Diseases: Pathogentic Role of Active Metabolites" Tunde Horvath, etc., Acta Physiologica Hungarica, vol. 73 (2-3), pp. 293-304 (1989).
"Drug Induced Hepatotoxicity", Neil Kaplowitz, M. D.; Tak Yee A W, Ph.D.; Francis R. Simon, M.D. Andrew Stolz, M.D., Annals of Internal Medicine, 1986:104:826-839-Jun., 1986.
"Immune Mechanisms in Tienilic Acid Associated Hepatotoxicity", James Neuberger and Roger Williams, Gut, 1989, 30, 515-519.
"Substrate Specificities and Functions of the P450 Cytochromes", M. R. Juchau, Life Sciences, vol. 47, pp. 2385-2394 (1990).
"A Form of Cytochrome P450 in Man.orthologous to form d in the rat.catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking", D. Sesardic, A. R. A. R. Boobis, R. J. Edwards and D. S. Davies, Br. J. dm Pharmac. (1988), 26, pp. 363-372.
"Species variation in the response of the cytochrome P450-dependent monooxygenase system to inducers and inhibitors", A. R. BooBis eta., Xenobiotica, 1990, vol. 20, No. 11, 1139-1161.
"Induction of Cytochromes P450IA1 and P450IA2 As Determined By Solution Hybridization" Prafulla Raval, Patrick L. Iversen, Edward Bresnick, Biochemical Pharmacology, vol. 41 No. 11, pp. 1719-1723, 1991.
"Comparison of Levels of Several Human Microsomal Cytochrome P-450 Enzymes and Epoxide in Normal and Disease States Using Immunochemical Analysis of Surgical Liver Samples" The Journal of Pharmacology and Experimental Therapeutics, vol. 256, No. 3, 1189-1194 (1990).
"Oxidation of Toxic and Carcinogenic Chemicals by Human Cytochrome P-450 Enzymes" F. Peter Guengerich, Tsutomu Shimada, Chem. Res. Toxicol, vol. 4, No. 4, 1991, pp. 391-407.
"Covalent Binding to Proteins as a Mechanism of Chemical Toxicity", C. Pantarotto, C. Blonda Disease, Metabolism and Reporduction in the Toic Response to Drugs and Other Chemicals Arch. Toxicol. Suppl. 7, 208-218 (1984).
"Irreversible Protein Binding of (C)imipramine with Rat and Human Liver Microsomes" Herman Kappus and Herbert Remmer, Biocemical Pharmacoclogy, vol. 24 pp. 1079-1084 (1975).
"Formation of Cytotoxic Metabolites From Phenytoin, Imipramine, Desipramine, Amitriptyline and Mianserin by Mouse and Human Microsomes", Riley, R. J; Roberts P; Kitteringham N R, Park B K, Biochemical Pharacolcogical 39: 1951-8, 15 Jun. 1990.
"Mechanism of Increased Hepatotoxicity of Acetaminophen by the Simultaneous Administration of Caffeine in the Rat", Chifumi Sato; Namiki Izumi, The Journal of Pharmacology and Experimental Therapuetics, vol. 248, No. 3, pp. 1243-1247 (1988).
"Bioactivatin of 4-Flourinated Anilines To Benzoquinoneimines As Primary Reaction Products", IMCM Rietjens and J. Vervoort, Chem-Biol. Interactions, 77 (1991) 263-281.
"Reactions and Significance of Cytochrome P-450 Enzymes", F. Peter Guengerich, The Journal of Biological Chemistry, vol. 266, No. 16, pp. 10019-10022 1991-Jun.
"Selectivity in the Inhibition of Mammalian Cytochromes p-450 by Chemical Agents" Michael Murray and Gordon F. Reidy, Pharmacological Reviews, vol. 42, No. 2, 1990 85-99.
"Quinoline Inhibition of Cytochrome P-450-Dependent Caffeine Metabolism in human Liver Microsomes", U. Fuhr, etc., Drug Metabolism and Disposition, vol. 18, No. 6, pp. 1005-1010, 1991.
"Inhibition of the Oxidative Metabolism of Thyeophylline in Isolated Rat Hepatocytes by the Quinoline Antibiotic Enoxacin and its Metabolite Oxoenoxacin. But not by Ofloxacin", Gerard Mulder, etc., Biochemical Pharmocology, vol. 37, No. 13, pp. 2565-2568, 1988.
"Recent developments in Hepatic Drug Oxidation: Implications For Clinical Pharmacokinetics" Kim Brosen, Clin. Pharmacokinet. 18 (3): 220-239. 1990.
"Metobolism by Rat Hepatic Microsomes of Flourinated Ether Anesthetics Following Isoniazid Administration" Susan A. Rice, Ph.D., etc., Anesthesiology, 53, pp. 489-493, 1980.
"Use of Adult Human Hepatocytes in Primasry Culture For the Study of Clometacin-Induced Immunoallergic Hepatitis" L. Siproudhis, etc., Toxic. in Vitro, vol. 5, No. 5/6, pp. 529-534, 1991
"Isoniazid Potentiation of a Guinea Pig Model of Halothane-associated hepatotoxicity" Richard C. Lind and A. Jay Gandolfi, etc., Society of Toxocology 28th Annual Meeting 1989.
"Mexiletine Metabolism in Virto by Human Liver", F. Broly, etc., Drug Metabolism and Disposition, vol. 18, No. 3, 1990.
"Disposition of Ethimizol, A Xanthine-related Nootropic Drug, in Perfused Rat Liver and Isolated Hepatocytes" Stefan Bezek, etc., Drug Metabolism and Disposition, vol. 18, No. 1, 1990.
"Inhibitors of Cytochrome P-450s and Their Mechanism of Action", Bernard Tests, Peter Jenner, Drug Metabolism Reviews, 12(1), 1-117 (1981).
"Drug-Induced Liver Disease", Lewis, J H, Current Opinion Gastroenterol 6(3): 381-90, 1990
"Comparison of the Chrometographic Characteristics of Metabolites of Taceine Hyochloride in Human Serum and Urine with Those of In Vitro Metabolic Products From Hepatic Microsomes" Biochemical Pharmacolcogy, vol. 42, No. 4, pp. 956-959, 1991.
"Review of Cimetidine Drug Interactions", Eugene M. Sorkin and Diane L. Darvey Drug Intelligence and Clinical Pharmacy, vol. 17, 110-120, Feb. 1983.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tacrine and cytochrome P450 oxidase inhibitors and methods of us does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tacrine and cytochrome P450 oxidase inhibitors and methods of us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tacrine and cytochrome P450 oxidase inhibitors and methods of us will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1221133

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.