Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-27
2007-03-27
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S575000
Reexamination Certificate
active
10473195
ABSTRACT:
The present invention relates to diazepine derivatives of formula (I)whereinR represents hydrogen or C1-4alkyl;R1represents hydrogen or C1-4alkyl;R2represents trifluoromethyl, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or halogen;R3represents halogen or C1-4alkyl;R4represents hydrogen, halogen, C1-4alkyl or COR6;R5represents hydrogen, C1-4alkyl or R5together within the R1represents C3-7cycloalkyl;R6represents hydroxy, amino, methylamino, dimethylamino,5membered heteroaryl group containing1to3heteroatoms selected independently from oxygen, sulphur and nitrogen or a6membered heteroaryl group containing1to3nitrogen atoms;m or n are independently zero or an integer from1to3;X and Y are independently NR7or methylene;provided that when X is NR7, Y is methylene and when X is methylene, Y is NR7;R7represents hydrogen, C1-4alkyl or C3-7cycloalkyl;and pharmaceutically acceptable salts and solvates thereof; to process for their preparation and their use in the treatment of condition mediated by tachykinins.
REFERENCES:
patent: 4045433 (1977-08-01), Rohricht et al.
patent: 5719147 (1998-02-01), Dorn et al.
patent: 6642240 (2003-11-01), Alvaro et al.
patent: 0899264 (1999-03-01), None
patent: WO 01/25219 (2001-04-01), None
patent: WO 02/32867 (2002-04-01), None
Severini et al., The Tachykinin Peptide Family, Pharmacological Reviews, vol. 54, No. 2, pp. 285-322, Jun. 2002.
Armour, D.R., et al. “1,4-benzodiazepin-2-one derived neurokinin-1 receptor antagonists.” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 7, No. 15, Aug. 5, 1997, pp. 2037-2042.
Argyropoulos, et al.; Exp. Opin. Invest. Drugs; 2000; 9/8; 1871-1875.
Ballard, et al.; European Journal of Pharmacology; 2001; 412; 255-264.
Ferraguti et al.; Mol Cell. Neurosci.; 1994; 5:269-276.
Kramer et al.; Science; 1998; 281; 1640-1645.
Coleman Brenda
Glaxo Group Limited
Morgan Lorie A.
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