Tachykinin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C540S575000

Reexamination Certificate

active

10473195

ABSTRACT:
The present invention relates to diazepine derivatives of formula (I)whereinR represents hydrogen or C1-4alkyl;R1represents hydrogen or C1-4alkyl;R2represents trifluoromethyl, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or halogen;R3represents halogen or C1-4alkyl;R4represents hydrogen, halogen, C1-4alkyl or COR6;R5represents hydrogen, C1-4alkyl or R5together within the R1represents C3-7cycloalkyl;R6represents hydroxy, amino, methylamino, dimethylamino,5membered heteroaryl group containing1to3heteroatoms selected independently from oxygen, sulphur and nitrogen or a6membered heteroaryl group containing1to3nitrogen atoms;m or n are independently zero or an integer from1to3;X and Y are independently NR7or methylene;provided that when X is NR7, Y is methylene and when X is methylene, Y is NR7;R7represents hydrogen, C1-4alkyl or C3-7cycloalkyl;and pharmaceutically acceptable salts and solvates thereof; to process for their preparation and their use in the treatment of condition mediated by tachykinins.

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