Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-10-23
2010-02-02
Ulm, John D (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C436S501000
Reexamination Certificate
active
07655422
ABSTRACT:
The invention relates to binding assays using human T1R2 polypeptides containing the extracellular and/or transmembrane regions of endogenous human T1R2 polypeptide. These assays may be used to identify T1R2 modulators, especially taste modulatory compounds.
REFERENCES:
patent: 5993778 (1999-11-01), Firestein et al.
patent: 6383778 (2002-05-01), Zuker et al.
patent: 6540978 (2003-04-01), Margolskee et al.
patent: 6955887 (2005-10-01), Adler et al.
patent: 7022488 (2006-04-01), Servant et al.
patent: 7208290 (2007-04-01), Li et al.
patent: 7223551 (2007-05-01), Adler et al.
patent: 7241880 (2007-07-01), Adler et al.
patent: 7244584 (2007-07-01), Zuker et al.
patent: 7244835 (2007-07-01), Adler et al.
patent: 7294474 (2007-11-01), Zoller et al.
patent: 7297543 (2007-11-01), Zoller et al.
patent: 7297772 (2007-11-01), Zoller et al.
patent: 7301009 (2007-11-01), Zoller et al.
patent: 7303886 (2007-12-01), Zoller et al.
patent: 7309577 (2007-12-01), Zoller et al.
patent: 7344859 (2008-03-01), Zoller et al.
patent: 7364903 (2008-04-01), Zoller et al.
patent: 7368285 (2008-05-01), Zoller et al.
patent: 7419791 (2008-09-01), Adler et al.
patent: 7435552 (2008-10-01), Adler et al.
patent: 7452685 (2008-11-01), Adler et al.
patent: 7465550 (2008-12-01), Zuker et al.
patent: 7507544 (2009-03-01), Adler et al.
patent: 2002/0051997 (2002-05-01), Zuker et al.
patent: 2002/0094551 (2002-07-01), Adler
patent: 2002/0151052 (2002-10-01), Chaudhari et al.
patent: 2002/0160424 (2002-10-01), Adler et al.
patent: 2002/0168635 (2002-11-01), Zuker et al.
patent: 2003/0008344 (2003-01-01), Adler et al.
patent: 2003/0022278 (2003-01-01), Zuker et al.
patent: 2003/0022288 (2003-01-01), Zuker et al.
patent: 2003/0036089 (2003-02-01), Wei et al.
patent: 2003/0040045 (2003-02-01), Zuker et al.
patent: 2003/0054448 (2003-03-01), Adler et al.
patent: 2003/0166137 (2003-09-01), Zuker et al.
patent: 2003/0232407 (2003-12-01), Zoller et al.
patent: 2004/0086877 (2004-05-01), Lal et al.
patent: 2005/0106571 (2005-05-01), Erlenbach et al.
patent: 2007/0105159 (2007-05-01), Erlenbach et al.
patent: 95/08627 (1995-03-01), None
patent: 00/06592 (2000-02-01), None
patent: 00/06593 (2000-02-01), None
patent: 01/64882 (2001-09-01), None
patent: 01/66563 (2001-09-01), None
patent: 01/83749 (2001-11-01), None
patent: 02/64631 (2002-08-01), None
patent: 03/001876 (2003-01-01), None
patent: 03/025137 (2003-03-01), None
patent: 2005/015158 (2005-02-01), None
Guo, et al., “Protein Tolerance to Random Amino Acid change”, PNAS, vol. 101, No. 25, p. 9205-9210, Jun. 22, 2004.
Nelson, et al., “An Amino-acid Taste Receptor”, Nature, vol. 416, p. 199-202, Mar. 14, 2002.
Li, et al., “Human Receptors for Sweet and Umami Taste”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, vol. 99, No. 7, Apr. 2, 2002, pp. 4692-4696—XP002254830.
Waterston, R.H., “Direct Submission”, Genome Sequencing Center, Apr. 21, 2000—XP002262036.
Adler, et al., “A Novel Family of Mammalian Taste Receptors”, Cell, vol. 100, pp. 693-702, Mar. 17, 2000—XP-000982304.
Montmayeur, et al., “A Candidate Taste Receptor Gene Near a Sweet Taste Locus,” Nature Neuroscience, May 2001, pp. 492-498, vol. 4, No. 5, Nature America, Inc., US.
Kitagawa, et al., “Molecular Genetic Identification of a Candidate Receptor Gene for Sweet Taste,” Biochemical and Biophysical Research Communications, Apr. 27, 2001, pp. 236-242, vol. 283, No. 1, Academic Press, San Diego, California, US.
Max, et al., “Tas1r3, Encoding a New Candidate Taste Receptor, is Allelic to the Sweet Responsiveness Locus Sac,” Nature Genetics, May 2001, pp. 58-63, vol. 28, No. 1, Nature America, New York, US.
Sainz, et al., “Identification of a Novel Member of the T1R Family of Putative Taste Receptors,” Journal of Neurochemistry, May 2001, pp. 896-903, vol. 77, No. 3, New York, NY, US.
Johnson, et al., “The Effect of the Sweetness Inhibitor 2(4-methoxyphenoxy) Propanoic Acid (Sodium Salt) (Na-PMP) on the Taste of Bitter-sweet Stimuli,” Chemical Sense, Aug. 1994, pp. 349-358, vol. 19, No. 4. Oxford, UK.
Temussi, et al., “The history of sweet taste: not exactly a piece of cake”, Journal of Molecular Recognition, 2006, 19: 188-199.
Bönigk, et al., “The Native Rat Olfactory Cyclic Nucleotide-Gated Channel is Composed of Three Distinct Subunits”, The Journal of Neuroscience, vol. 19, No. 136, p. 5332-5347, Jul. 1, 1999.
Alexander, et al., “Altering the Antigenicity of proteins”, Proc. Natl. Acad. Sci. USA, vol. 89, p. 3352-3356, Apr. 1992.
GenBank Accession No. AL139287, clone RP5-89003, Feb. 13, 2000.
Lindemann, “A Taste for Umami”, Nature Neuroscience, vol. 3, No. 2, p. 99-100, Feb. 2000.
Krautwurst, et al., “Identification of Ligands for Olfactory Receptor by Functions Expression of a Receptor Library”, Cell, vol. 95, p. 917-926, Dec. 23, 1998.
Bowie, et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”,1990, Science 247: 1306-1310.
Hoon, et al., “Putative Mammalian Taste Receptors : A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity”, Cell, vol. 96, pp. 541-551, Feb 19, 1999—XP-000922524.
Perruccio, et al., Society for Neuroscience Abstracts 26 (1-2) Abstact No. 66.15, 2000.
GenBank Accession No. AA907022, May 19, 1998.
Damak, S., “Detection of Sweet and Umani Taste in the Absence of Taste Receptor T1 r3,” vol. 301, pp. 850-853, 2003.
Kinnamon, et al., “Chemosensory Transduction Mechanisms in Taste”, Annu. Rev. Physoil., vol. 54, p. 715-731, 1992.
Extended European Search Report and Opinion for European Application No. 08075748.7 dated Nov. 21, 2008.
European Search Report for European Application No. 08153652.6 dated Jan. 21, 2009.
Jiang, et al., “Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste”, The Journal of Biological Chemistry, vol. 280, No. 15, pp. 15238-15246, Apr. 15, 2005.
Xu, et al., “Different functional roles of T1R subunits in the heteromeric taste receptors”, PNAS, vol. 101, No. 39, pp. 14258-14263, Sep. 28, 2004.
Adler Jon Elliot
Li Xiaodong
O'Connell Shawn
Staszewski Lena
Zozulya Sergey
Hunton & Williams LLP
Senomyx Inc.
Ulm John D
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