Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2007-10-30
2007-10-30
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C435S069300
Reexamination Certificate
active
08445307
ABSTRACT:
The present invention provides isolated peptides of the major protein allergens of the genusDermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
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Chen Xian
Evans Sean
Franzen Henry M.
Garman Richard D.
Greenstein Julia L.
Boesen Agnieszka
Campell Bruce R.
Lahive & Cockfield LLP
Merck Patent GmbH
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