Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-07-04
2006-07-04
O'Hara, Eileen B. (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S252300, C435S252800, C435S325000, C435S069100, C435S007100, C435S007200, C435S007370, C435S071100, C435S071200, C435S350000
Reexamination Certificate
active
07070944
ABSTRACT:
Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a system comprising genetic material encoding a fatty acid transport mediator (“TTM”), particularly FAA1, FAA2, FAA3, FAA4, FAT1, fadL, fadD, FATP, CD36 and FABP, or orthologs, homologs, isoforms, variants, analogs, derivatives or fragments thereof, and combinations thereof, or fatty acid transport mediator proteins (“TTMps”), e.g., Faa1p, Faa2p, Faa3p, Faa4p, Fat1p, FadL, fatty acyl CoA synthetase, FATP, CD36 and FABP, or orthologs, homologs, isoforms, variants, analogs, derivatives or fragments thereof, and combinations thereof, and determining the effect of the putative modulator. The test system may be a cell such asSaccharomyces cerevisiae, E. coli, H. sapiens,etc. or an in vitro system.
REFERENCES:
patent: 6284487 (2001-09-01), Stahl et al.
patent: 6288213 (2001-09-01), Stahl et al.
patent: 6300096 (2001-10-01), Stahl et al.
patent: 6348321 (2002-02-01), Stahl et al.
patent: 6657049 (2003-12-01), Stahl
patent: 2002/0106733 (2002-08-01), Stahl et al.
patent: 2003/0232363 (2003-12-01), Stahl et al.
Knoll et al. Biochemical Studies of ThreeSaccharomyces cerevisiaeAcyl-CoA Synthetase, Faa1p, Faa2p, Faa3p. The Journal of Biological Chemistry. vol. 269, No. 23, pp. 16348-16356, 1994.
Raman, et al. (1997). “Characterization of the Fatty Acid-responsive Transcription Factor FadR.”J. Biol. Chem., 272: 30645.
Faergman, et al. (1997). “Disruption of theSaccharomyces cerevisiaeHomologue to the Murine Fatty Acid Transport Protein Impairs Uptake and Growth on Long-chain Fatty Acids.”J. Biol. Chem., 272: 8531.
DiRusso, et al. (2000). “Murine FATP alleviates growth and biochemical deficiencies of yeastfat1Δ strains.”Eur. J. Biochem., 267: 1-13.
Black, et al. (2000). “Long Chain Acyl-CoA-Dependent Regulation of Gene Expression in Bacteria, Yeast and Mammals.”Symposium: The Role of Long Chain Fatty Acyl-CoAs as Signaling Molecules in Cellular Metabolism, Amer. Soc. Nutritional Sciences, 305S.
Faergman, et al. (2001). “The Acyl-CoA Synthetase Encoded withinFAA1FAA4inSaccharomyces cerevisiaeFunction as Components of the Fatty Acid Transport System Linking Import, Activation, and Intracellular Utilization.”J. Biol. Chem. 276: 37051.
Black Paul
DiRusso Concetta
Biswas, Esq. Naomi S.
CLF Medical Technology Acceleration Program, Inc.
Elrifi, Esq. Ivor R.
Hamud Fozia
Mintz, Levin, Cohn,Ferris, Glovsky and Popeo, P.C.
LandOfFree
System for screening fatty acid transport inhibitors,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System for screening fatty acid transport inhibitors,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System for screening fatty acid transport inhibitors,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3545775