Synthetic process for the preparation of anti-tumor agent-etopos

Details Synthetic process for the preparation of anti-tumor agent-etopos Synthetic process for the preparation of anti-tumor agent-etopos

1991-06-07

1993-04-27

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 182, 536 185, C07H 1704, C07H 100, A61K 3170

Patent

active

052063500

ABSTRACT:
This invention relates to a new synthetic process for the preparation of anti-tumor agent Etoposide (VP16-213). the process, which has shorten reaction route, simple procedure, high yield and low materials cost, therefore facilitates the commercial manufacture of etoposide.

REFERENCES:
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patent: 4547567 (1985-10-01), Umezawa et al.
patent: 5036055 (1991-07-01), Ohnuma et al.
patent: 5081234 (1992-01-01), Ohnuma et al.
Arnold et al; The Lancet II; 912-915 (Oct. 24, 1981).
Saito et al.; Chemistry Letters 5:799-802 (1987).
Allevi et al.; Tetrahedron Letters 32(47):6927-6930 (Nov. 18, 1991).

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