Transforming growth factor .alpha.H1

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435348, 4352523, 4353201, 435419, 435360, 4353651, 435325, 536 235, C12N 1563, C12N 1512

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056331479

ABSTRACT:
Disclosed is a human TGF.alpha.-H1 polypeptide and DNA (RNA) encoding such TGF.alpha.-H1 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and for producing antibodies and antagonists against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided, are methods of using the antibodies and antagonists to inhibit TGF.alpha.-H1 for therapeutic purposes.

REFERENCES:
patent: 5115096 (1992-05-01), Shoyab et al.
patent: 5256643 (1993-10-01), Persico et al.
Mann, B.G. et al., Mice with a Null Mutation of the TGF alpha Gene Have Abnormal Skin Architecture, Wavy Hair and Curly Whiskers and Often Develop Corneal Inflammatory Cell 73:249-261 (1993).
Cook, P.W. et al., Amphiregulin MRNA is elevated in Psoriatic Epidermis and Gastrointestinal Carcinomas, Cancer Research, 52:3224-3227 (1992).
Woo, D.D.L. et al., Chemical Synthesis in Protein Engineering purification and covalent structural characterication of a Mitogenic Protein Human TGF alpha, Protein Engineering, 3:29-37 (1989).
Prigent, S.A., et al., The Type 1 (EGFR-Related) Family of Growth Factor Receptors and Their Ligands, Progress in Growth Factor Research, 4:1-24 (1992).
Derynck, R., TGF-alpha, Molecular Reproduction and Development, 27:3-9 (1990).
Kudlow, J.E., et al., TGF alpha in Normal Physiology, Cancer Biology, 1:293-302 (1990).
Holmes, W.E., et al., Identification of Heregulin a Specific Activation of pl85erbB2, Science, 256:1205-1210 (1992).
Schultz, G.D. et al., EGF and TGF alpha in Wound Healing and Repair, J. of Cellular Biochem., 45:346-352 (1991).

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