Synthetic cephalotaxine esters having antileukemic activity

Details Synthetic cephalotaxine esters having antileukemic activity Synthetic cephalotaxine esters having antileukemic activity

1978-02-22

1979-05-01

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265B, 424274, A61K 3155, C07D49102

Patent

active

041523334

ABSTRACT:
Six acyl esters of cephalotaxine have been synthesized by ordinary and standard procedures, and all have demonstrated chemotherapeutic activity against leukemia in animals.

REFERENCES:
patent: 3870727 (1975-03-01), Powell et al.
patent: 3959312 (1976-05-01), Mikolajczak et al.
Mikolajczak et al., J. Pharm. Sci., vol. 63, pp. 1280-1283 (1974).
Powell et al., J. Pharm. Sci. vol. 61, pp. 1227-1230 (1972).
Powell et al.; Tetrahedron Letters, vol. 46, pp. 4081-4084 (1969).
Abraham et al., Tetrahedron Letters, vol. 46, pp. 4085-4086 (1969).

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