Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetan

Details Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetan Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetan

1993-07-02

1998-06-09

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568661, 568633, 568632, 560130, C07C 4303, C07C 6900

Patent

active

057636818

ABSTRACT:
A novel synthesis of compound having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R.sup.3 is a C.sub.1 -C.sub.20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula:

REFERENCES:
patent: 4366154 (1982-12-01), Tomesch
patent: 4956477 (1990-09-01), Bronstein et al.
patent: 4962192 (1990-10-01), Schaap
A.E. Arbusow et al., Chem. Ber., 60, pp. 291-295 (1927).
M. Bhatt et al., Synthesis, pp. 249-282 (1983).
Boutagy et al., Chemical Reviews, 74, pp. 87-99 (1974).
Burkhouse et al., Synthesis, pp. 330-332 (1984).
Creary et al., The Journal of Organic Chemistry, pp. 2165-2170 (1985).
Feutrill et al., Tetrahedron Letters, 16, pp. 1327-1328 (1970).
Feutrill et al., Aust. J. Chem., 25, pp. 1731-1735 (1972).
T.W. Greene, "Protective Groups in Organic Synthesis", pp. 88-92 (1981).
Grell et al., Chemical Abstract, 66, pp. 53-67 (1966).
Gushurst et al., The Journal of Organic Chemistry, 53:15, pp. 3397-3408 (1988).
Horner et al., Chem. Ber., 95:581 (1962).
Kim et al., Synthetic Communications, 16(8), pp. 859-863 (1986).
King et al., Biochemical Journal, 33, pp. 1182-1184 (1939).
Magnus et al., Organometallics, 1, pp. 553-559 (1982).
McMurry et al., The Journal of Organic Chemistry, 43:17, pp. 3255-3266 (1978).
Meijer et al., Tetrahedron Letters, 41, pp. 3997-4000 (1979).
Schaumann et al., Liebigs. Ann. Chem., pp. 88-100 (1977).
Shah et al. Carbohydrate Research, 74, pp. 105-116 (1979).
Slotin et al., Synthesis, pp. 737-751 (1977).
Thuong et al., Bulletin of the Chemical Society of France, 9-10, pp. 2083-2088 (1975).
Thuong et al., Bulletin of the Chemical Society of France, 3-4, pp. 667-671 (1974).
Wadsworth et al., The Journal of American Chemical Society, 83, pp. 1733-1738 (1961).
Walker et al., Organophos. Reags. in Org. Synth., pp. 155-205 (1978).
Grell et al., Chemical Abstract, 66:53 (1966) 76092q.
Burkhouse et al., Chemical Abstract, 101 (1989) 171344q.
Kim et al., Chemical Abstract, 107 (1985) 39936a.
Livantsov et al., Chemical Abstract, 105, (1986) 191247s.
Tomioka et al., Chemical Abstract, 111 (1989) 194888z.

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