Synthesis of platinum complexes and uses thereof

Details Synthesis of platinum complexes and uses thereof Synthesis of platinum complexes and uses thereof

1998-04-29

2000-08-29

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

549206, A61K 31555, C07F 1500

Patent

active

06110907&

ABSTRACT:
This invention provides novel antitumor demethylcantharidin platinum complexes. This invention also provides a composition comprising at least one of said demethylcantharidin platinum complexes and a suitable carrier. This invention provides a pharmaceutical composition comprising effective amount of at least one of the said demethylcantharidin platinum complexes and a pharmaceutically acceptable carrier. This invention provides a method of inhibiting the growth of tumorous cells comprising contacting the cells with an amount of said demethylcantharidin platinum complex effective to inhibit the growth of said tumorous cells. This invention provides a method of inhibiting the growth of tumorous cells in a subject comprising administering to the subject with an amount of the said demethylcantharidin platinum complexes effective to inhibit the growth of said tumorous cells in the subject. Finally, this invention provides methods for producing said demethylcantharidin platinum complexes.

REFERENCES:
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4675336 (1987-06-01), Bitha et al.
Zou et al CA126:194919, 1997.
Zou, Juan, et al., "Synthesis Antitumor, Activity and Acute Toxicity of Dmine/Diamino-Cylohexane Platinum (II) Complexes With Oxygen-Ligating Leaving Group" Journal of Inorganic Biochemistry (1997) vol. 65: No. 2, pp. 145-149.
"Chemical Abstracts" (Nov. 15, 1997) vol. 126:194919v No. 15, p. 25.
The International Search Report of PCT/CN98/00069 corresponding to the above-identified subject application, dated Jul. 2, 1998, and a copy of the filed PCT International .

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