Synthesis of indoles by dehydrogenation of indolines

Details Synthesis of indoles by dehydrogenation of indolines Synthesis of indoles by dehydrogenation of indolines

1994-08-25

1996-07-16

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548492, C07D20904, C07D20930

Patent

active

055368433

ABSTRACT:
##STR1## By dehydrating indolines or their salts, the corresponding indoles having formula (I) are obtained. In the formula, R.sup.1 and R.sup.3 represent independently from each other hydrogen or alkyl groups with 1 to 4 C atoms, R.sup.2 stands for hydrogen, a methyl or a carboxyl group, R.sup.4 and R.sup.5 represent independently from each other hydrogen, amino groups, hydroxy groups, alkyl groups with 1 to 4 C atoms or alkoxy groups with 1 to 4 C atoms, or, in case R.sup.4 and R.sup.5 are bound to adjacent C atoms, both residues may also represent together an alkylene dioxy group with 1 to 4 C atoms. This process allows high yields of very pure indoles to be produced.

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