Synthesis of 2-pyridylalkylamines substituted on the pyridyl rin

Details Synthesis of 2-pyridylalkylamines substituted on the pyridyl rin Synthesis of 2-pyridylalkylamines substituted on the pyridyl rin

1983-03-22

1985-05-07

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21361

Patent

active

045159521

ABSTRACT:
The invention provides a process for preparing 2-pyridylalkylamines, substituted in one of the 3- or 5-positions by bromo and in the other by C.sub.1-4 alkyl, by reacting an appropriate C.sub.1-4 alkyl substituted 2-pyridylalkylamine with an electrophilic brominating agent. Said 2-pyridylalkylamines are useful as intermediates in the synthesis of compounds useful as histamine H.sub.1 -antagonists.

REFERENCES:
patent: 4154834 (1979-05-01), Brown et al.
van der Does et al., Recueil, 84:951-964, (1965).
Mertel, Pyridine and its Derivatives, Interscience, (1961), pp. 316-317.
House, Modern Synthetic Reactions, Benjamin Inc. (1965), pp. 138-139.

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