Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1985-04-01
1986-02-04
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
514731, 514734, A61K 3105, A61K 3112
Patent
active
045686963
ABSTRACT:
Non-steroidal anti-inflammatory compositions comprising a compound of the formula: ##STR1## wherein R.sub.1 is H or OH; and X, Y, X.sup.1 and Y.sup.1 represent hydrogen or halogen, such as chloro, fluoro, bromo, or iodo radicals, lower alkyl radicals such as C.sub.1 -C.sub.8 radicals, such as methyl, ethyl, propyl and butyl, lower haloalkyl radicals, such as trifluoro, trichloro or tribromo methyl radicals, and lower alkoxy radicals, such as C.sub.1 -C.sub.8 radicals such as methoxy, ethoxy, propoxy, and octyloxy radicals or combinations thereof and the salts thereof, in combination with a compound selected from the group consisting of butylated hydroxytoluene, nordihydroguaiaretic acid and mixtures thereof, said combination being contained in a pharmaceutically acceptable carrier.
A method of treating pain and inflammation is also disclosed.
REFERENCES:
patent: 4145444 (1979-03-01), Hamazaki et al.
patent: 4244970 (1981-01-01), Dewhirst
Dewhirst, Floyd Everett, "Eugenol, A Prototype Phenolic Prostaglandin Synthetase Inhibitor, its Anti-Inflammatory Activity, Its Effect on Sheep Vesicular Gland Cyclooxygenase, and Structure-Activity Relationships for Cyclooxygenase Inhibition by Sixty-Three Phenolic Compounds", PhD. Thesis, University of Rochester 1978, available from University Microfilms International, Ann Arbor, Michigan.
Pittz Eugene P.
Smerbeck Richard V.
Friedman Stanley J.
Kadlubowski Marian F.
Nath Gary M.
Scola Daniel A.
Warner-Lambert & Company
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