Synergistic combinations in the treatment of anxiety

Details Synergistic combinations in the treatment of anxiety Synergistic combinations in the treatment of anxiety

1991-04-23

1992-06-23

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514647, A61K 31415, A61K 31135

Patent

active

051243466

ABSTRACT:
Combinations having synergistic anxiolytic activity which comprise a first component selected from the group consisting of 8-hydroxy-2-(dipropylamino)-tetralin, gepirone, ipsapirone, tandospirone, (7S,9S)-2-pyrimidyl)-7-(succinimidomethyl)-perhydro-1H-pyrido[1,2-a]pyrazi ne, or chlordiazepoxide; and a second component selected from the group consisting of 1-(2-pyrimidyl)pyrazine and idazoxan.

REFERENCES:
Soderpalm et al., J. Neural. Transm., v. 76, pp. 191-204 (1989).
Gower et al., Eur. J. Pharmacol., v. 155, pp. 129-137 (1988).
Engel et al., Eur. J. Pharmacol., v. 105, pp. 365-368 (1984).

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