Synergistic administration of cyclosporine and fructose diphosph

Details Synergistic administration of cyclosporine and fructose diphosph Synergistic administration of cyclosporine and fructose diphosph

1994-07-26

1998-05-05

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 9, 514 25, 514885, 514922, 530317, A61K 3170

Patent

active

057474613

ABSTRACT:
This invention discloses a method of using fructose-1,6-diphosphate (FDP) to help suppress the rejection of internal organs such as kidneys, hearts, etc. At least three major advantages of FDP in conjunction with organ transplants have been identified: (1) FDP can help reduce the unwanted proliferation of certain types of stimulated lymphocytes which would otherwise pose a risk of attacking the non-self cells in the transplanted organ; (2) FDP can also potentiate the effectiveness of cyclosporine as a transplant-protecting immunosuppressant, thereby allowing a reduction in CSA dosages, which in turn can reduce the likelihood and the severity of toxic side effects and other dangers of CSA treatment; (3) FDP can also reduce the amount of damage inflicted on an organ during the removal and storage steps required in organ transplantation.

REFERENCES:
patent: 4448771 (1984-05-01), Cattani et al.
patent: 4546095 (1985-10-01), Markov
patent: 4757052 (1988-07-01), Markov
patent: 4916220 (1990-04-01), Galzigna et al.
patent: 5039655 (1991-08-01), Markov
patent: 5039665 (1991-08-01), Markov
patent: 5196402 (1993-03-01), Braganza et al.

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