Swelling modulated polymeric drug delivery device

Details Swelling modulated polymeric drug delivery device Swelling modulated polymeric drug delivery device

1989-11-07

1992-06-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424424, A61K 924, A61K 200, A61K 3174

Patent

active

051205483

ABSTRACT:
A controlled release drug delivery device, comprised of swellable polymers, whose degree of swelling in an environment of use is controlled by swelling modulators blended within the polymers, is disclosed. The swelling modulators can include buffers, osmagents, surfactants or combinations thereof surrounded by a microporous coating or interspersed within individual matrices. The combination of controlled release swelling modulators with swellable polymers may be applied to regulate patterns of beneficial agent (typically a drug) release.

REFERENCES:
patent: 4309996 (1982-01-01), Theeuwes
patent: 4350271 (1982-09-01), Eckenhoff
patent: 4642233 (1987-02-01), Urquhart et al.
patent: 4723957 (1988-02-01), Magruder et al.
patent: 4747847 (1988-05-01), Magruder et al.
patent: 4755180 (1988-07-01), Ayer et al.
patent: 4839177 (1989-06-01), Columbo et al.

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