Sustained release pharmaceutical composition of solid medical ma

Details Sustained release pharmaceutical composition of solid medical ma Sustained release pharmaceutical composition of solid medical ma

1982-07-29

1983-09-13

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 22, 424 78, A61K 914, A61K 926, A61K 952, A61K 958

Patent

active

044041837

ABSTRACT:
Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid, and may further contain one basic substance selected from the group consisting of a surface active agent, polyethylene glycol, propylene glycol, glycerin, a glycerin fatty acid ester and a vegetable oil (first embodiment); and in the case where the solid medical material is nicardipine, the composition may consist only of the amorphous nicardipine or a salt thereof without the above compound (second embodiment).

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Union Carbide "Polyox Water-Soluble Resins Are Unique" (3/81) 30 pp.
Chiou et al. J. Pharm. Sci. 58(12): 1505-1509 Dec. 1969 Preparation and Dissolution Characteristics of Several Fast-Release Solid Dispersions of Griseofulvin.
Goldberg et al. J. Pharm. Sci. 54: 1145-1148 (1965) Increasing Dissolution Rates and Gastro-Intestinal Absorption of Drugs Via Solid Solutions and Eutectic Mixtures.
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