Surfaces with reduced protein interactions

Details Surfaces with reduced protein interactions Surfaces with reduced protein interactions

1990-04-11

1992-05-19

Seidleck, James J.

Stock material or miscellaneous articles

Hollow or container type article

Polymer or resin containing

428420, 2041801, 2041828, 204299R, 128760, 128763, 604403, B29D 2200, C25D 1300

Patent

active

051147688

ABSTRACT:
A solid surface that is exposed to protein solutes in use, such as medical implants or capillary tubes useful in capillary zone electrophoresis, is defined by or carries a polymer. An interfacial layer is covalently bound to the polymer and functions to reduce interactions between the surface and protein solutes. The interfacial layer includes either a hydratable amphoteric phase or a plurality of halogen atoms bound in the interfacial layer through at least one heteroatom.

REFERENCES:
patent: 4680201 (1987-07-01), Hjerten
patent: 4690749 (1987-09-01), Van Alstine et al.

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