Suppression of electroosmosis with hydrolytically stable coating

Details Suppression of electroosmosis with hydrolytically stable coating Suppression of electroosmosis with hydrolytically stable coating

1990-10-26

1991-12-24

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

2041801, 204299R, C25B 100, B01D 6142

Patent

active

050749820

ABSTRACT:
Surfaces of silica-containing materials, such as the inner walls of silica capillaries, used in chromatographic, particularly electrophoretic, separations are coated with an organic polymer layer to reduce or eliminate surface charges. The layer is applied by first converting the silanol groups on the surface to silicon halide groups, then reacting these groups with an organometallic reagent having a terminal ethenyl moiety, preferably vinyl or allyl lithium or a vinyl or allyl magnesium halide, to convert the silicon halide groups to Si--R groups where the R retains the terminal ethenyl moiety, and finally reacting these ethenyl groups newly attached to the surface with a neutral organic monomer in an addition polymerization reaction to form a monomolecular noncrosslinked polymer layer over the surface. The resulting polymer layer is linked to the silica directly through a Si--C bond which is stable over a wide range of pH conditions.

REFERENCES:
patent: 4680201 (1987-07-01), Hjerten
patent: 4997537 (1991-03-01), Karger
Payne, "Simultaneous Deactivation and Coating of Porous Silica Particles for Microcolumn Supercritical Fluid Chrom.", Anal. Chem., 62, 1379-1384 (1990).
Burrows, "Thermostable deactivation reagents for capillary column preparation", Jour. of Chrom., 260, 168-172 (1983).

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