Support material for solid phase organic synthesis

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530335, 436518, 560 61, 560 62, 5483694, 558242, 564164, 564165, A61K 3800, G01N 33543

Patent

active

059170158

ABSTRACT:
A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I): ##STR1##

REFERENCES:
patent: 4062746 (1977-12-01), Rich et al.
patent: 4108846 (1978-08-01), Meienhofer
patent: 5117009 (1992-05-01), Barany
patent: 5196566 (1993-03-01), Barany et al.
patent: 5235028 (1993-08-01), Barany et al.
patent: 5306562 (1994-04-01), Barany
Barany, NIH Grant No. GM 42722 (Abstract).
Barany, NIH Grant No. GM 51628 (Abstract).
J.G. Adamson et al., "Use of Marfey's Reagent to Quantitate Racemization upon Anchoring of Amino Acids to Solid Supports for Peptide Synthesis", Analytical Biochemistry, 202, 210-214 (1992).
F. Albericio et al., "Allyl-based orthogonal solid phase peptide synthesis", Peptides, Proceedings of the Twenty-Second European Peptide Symposium, Sep. 13-19, 191-193 (1992).
F. Albericio et al., "An Acid-labile anchoring linkage for solid-phase synthesis of C-terminal peptide amides under mild conditions", Int. J. Peptide Protein Res., 30, 206-216 (1987).
F. Albericio et al., "Preparation and Application of the 5-(4-(9-Fluorenylmethyloxycarbonyl)aminomethyl -3,5-dimethoxyphenoxy)- valeric Acid (PAL) Handle for the Solid-Phase Synthesis of C-Terminal Peptide Amides under Mild Conditions", J. Org. Chem., 55, 3730-3743 (1990), plus Supplementary Materials (19 pages).
G. Barany et al., "A New Amino Protecting Group Removable by Reduction. Chemistry of the Dithiasuccinoyl (Dts) Function", J. Amer. Chem. Soc., 99, 7363-7365 (1977).
G. Barany et al., "Novel polyethylene glycol-polystyrene (PEG-PS) graft supports for solid-phase peptide synthesis", Peptides, 267-268 (1992).
G. Barany et al., "Solid-Phase Peptide Synthesis", The Peptides, vol. 2, Title Page, Copyright Page, Table of Contents, pp. v-viii (1979).
G. Barany et al., "Solid-phase peptide synthesis: a silver anniversary report", Int. J. Peptide Protein Res., 30, 705-739 (1987).
C. Boojamra et al., "An Expedient and High-Yielding Method for the Solid-Phase Synthesis of Diverse 1,4-Benzodiazepine-2,5-diones", J. Org. Chem., 60, 5742-5743 (1995).
Cohn et al., "IUPAC-IUB Commission on Biochemical Nomenclature Symbols for Amino-Acid Derivatives and Peptides Recommendations", J. Biological Chem., 247, 977-983 (1972).
C.G. Fields et al., "Edman Degradation Sequence Analysis of Resin-Bound Peptides Synthesized by 9-Fluorenylmethoxycarbonly Chemistry", Peptide Research, 6, 39-47 (1993).
C.G. Fields et al., "HBTU Activation for Automated Fmoc Solid-Phase Peptide Synthesis", Peptide Research, 4, 95-101 (1991).
G.B. Fields et al., "Principles and Practice of Solid-Phase Peptide Synthesis", in Synthetic Peptides: A User's Guide, G.A. Grant, Ed., W.H. Freeman & Co., New York, NY; 77-183 (1990).
G.B. Fields et al., "Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids", Int. J. Peptide Protein Res., 35, 161-214 (1990).
G.B. Fields et al., "The Versatility of Solid Phase Peptide Synthesis", Innovation and Perspectives in Solid Phase Synthesis, R. Epton, Ed., Solid Phase Conference Coordination, Ltd., Birmingham, United Kingdom, 241-260 (1990).
J. Green, "Solid Phase Synthesis of Lavendustin A and Analogues", J. Org. Chem., 60, 4287-4290 (1995).
F. Guibe et al., "Use of an Allylic Anchor Group and of its Palladium Catalyzed Hydrostannolytic Cleavage in the Solid Phase Synthesis of Protected Peptide Fragments", Tetrahedron Ltrs., 30, 2641-2644 (Jun. 1989).
K.J. Jensen et al., "A Novel Handle Approach for Solid-Phase Peptide Synthesis: Backbone Amide (BAL) Anchoring", Fourteenth American Peptide Symposium, pp. 30-32, Columbus, OH, Jun. 18-23, 1995.
K.J. Jensen et al., "Backbone Amide (BAL) Anchoring in Solid-Phase Peptide Synthesis", Fourth International Symposium on Solid Phase Synthesis, 4 pps., Edinburgh, Scotland, UK, Sep. 12-16, 1995.
T. Johnson et al., "N,O-bisFmoc Derivatives of N-(2-Hydroxy-4-methoxybenxyl)-amino acids: Useful Intermediates in Peptide Synthesis", J. Peptide Science, 1, 11-25 (1995).
R.B. Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Amer. Chem. Soc., 85, 2149-2154 (1963).
D. Mullen et al., "A New Fluoridolyzable Anchoring Linkage for Orthogonal Solid-Phase Peptide Synthesis: Design, Preparation, and Application of the Pentanedioic Acid Monoamide (Pbs) Handle", J. Org. Chem., 53, 5240-5248 (1988).
M. Mutter et al., "A Chemical Approach to Protein Design--Template-Assembled Synthetic Proteins (TASP)", Angew. Chem. Int. Ed. Engl., 28, 535-554 (1989).
E. Nicolas et al., "A New Approach to the Solid-Phase Peptide Synthesis of Peptide Alkyl-Amides and Esters", Tetrahedron Letters, 33, 2183-2186 (1992).
"Program and Abstracts", Fourteenth American Peptide Symposium, American Peptide Society, Title Page, Table of Contents, (1-1 to 1-22), Columbus, OH, Jun. 18-23, 1995.
M. Renil et al., "Synthesis of fully Protected Peptides on a Tetraethyleneglycol Diacrylate (TTEGDA)-Crosslinked Polystyrene support with a Photolytically Detachable 2-Nitrobenzyl Anchoring group", Tetrahedron Letters, 35, 3809-3812 (1994).
J. Rivier et al., "Anchoring of Amino Functions to Supports in Solid Phase Peptide Synthesis", Peptides, Proceedings of the 50th Anniversary Symposium, Szeged, Hungary, Aug. 31-Sep. 4, 1987, pp. 75-78.
Y. Sasaki et al., "Solid Phase Synthesis of Peptides Containing the CH.sub.2 NH Peptide Bond Isostere", Peptides, 8, 119-121 (1987).
S. Sharma et al., "Reductive Amination with Tritylamine as an Ammonia Equivalent: Efficient Preparation of the aleric Acid (PAL) Handle for Peptide Synthesis", J. Org. Chem., 58, 4993-4996 (1993).
M. Songster et al., "Acid-labile handles for Fmoc solid-phase synthesis of peptide N-alkylamides", Letters in Peptide Science, 2, 265-270 (1995).
J. Tam et al., "Strong Acid Deprotection of Synthetic Peptides: Mechanisms and Methods", The Peptides, 9, Chapter 5, 185-248 (1987).
F. Weygand et al., "Leicht Abspaltbare Schutzgruppen Fur Saureamidfunktionen" Tetrahedron Letters, 29, 3483-3487 (1966).
P. Williams et al., "Convergent Solid-Phase Peptide Synthesis", Tetrahedron, 49, 11065-11133 (1994).
K. Jensen et al., "A Novel Handle Approach for Solid Phase Peptide Synthesis: Backbone Amide Linker (BAL) Anchoring", Peptides: Chemistry, Structure and Biology, Chapter 6, 30-32, P. T. P. Kaumaya and R. S. Hodges, eds. (Aug. 1, 1996).
K.J. Jensen et al., "Backbone Amide (BAL) Anchoring in Solid-Phase Peptide Synthesis", Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Chemical Libraries: Biomedical & Applications, 1996, 187-190, R. Epton, ed., Mayflower Scientific Ltd., Kingswinford, England (Apr. 28, 1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Support material for solid phase organic synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Support material for solid phase organic synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Support material for solid phase organic synthesis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1376336

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.