.sup.82 Rb Generating method and eluent

Details .sup.82 Rb Generating method and eluent .sup.82 Rb Generating method and eluent

1980-06-04

1983-09-27

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

423 2, A61K 4300, A61K 4900

Patent

active

044068778

ABSTRACT:
The present invention provides a low .sup.82 Sr breakthrough eluent and method of generating .sup.82 Rb from .sup.82 Sr from a .sup.82 Sr charged inorganic adsorbant column. Eluting is done with a pharmaceutically acceptable saline and buffer solution, which is preferably isotonic .sup.82 Sr breakthroughs of 10.sup.-8 are obtained at clinically useful elution rates greater than 10 ml per minute. Phosphate and carbonate buffers are preferred. Al.sub.2 O.sub.3 and ZrO.sub.2 are preferred inorganic radiation damage resistant adsorbants.

REFERENCES:
patent: 3183152 (1965-05-01), Szekely et al.
patent: 3240709 (1966-03-01), Rankin
patent: 3333919 (1967-08-01), Buckingham
patent: 3664964 (1972-05-01), Haney et al.
patent: 3882036 (1975-05-01), Krezanoski et al.
patent: 3903297 (1975-09-01), Robert
patent: 3953567 (1976-04-01), Grant et al.
patent: 4057618 (1977-11-01), Salmon et al.
patent: 4064227 (1977-12-01), Brown et al.
patent: 4067959 (1978-01-01), Bolz
patent: 4276267 (1981-06-01), Bentley et al.
Kopecky et al., Int. J. Appl. Rad. Isotopes, 25 (1974) 469-470.
Grant et al., J. Nucl. Med., 16(4) 300-304 (1975).
Yano et al., J. Nuclear Med., vol. 9, No. 7, 412-415, 1974.
Yano et al., J. Nucl. Med., vol. 18, No. 1, 46-50, 1977.
Grant et al., J. Nucl. Med., vol. 19, No. 11, 1250-1255, 1978.
Yano et al., Int. J. Appl. Rad. Isotopes, 30:382-385, 1979.
Yano et al., J. Nucl. Med., vol. 20, No. 9, 961-966, 1979.
Kolprathipanja et al., Int. J. Appl. Rad. Isotopes, 30:447-449, 1979.
Budinger et al., J. Nucl. Med., vol. 16, No. 5, 429-431, 1975.
Krizek et al., J. Nucl. Med., 18:609, 1977.
Budinger et al., J. Nucl. Med., 20:603, 1979.
Neirinckx et al., Second Int. Symposium on Radio Pharmaceutical Chem., MRC, Oxford, 1978, p. 109.

Affiliated with

Also associated with

Rating

.sup.82 Rb Generating method and eluent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .sup.82 Rb Generating method and eluent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .sup.82 Rb Generating method and eluent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2130785