Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2008-04-29
2008-04-29
Berch, Mark L (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C549S059000, C549S065000, C549S075000, C549S366000, C549S469000, C549S471000, C549S479000, C564S090000, C564S091000, C564S092000, C564S093000, C564S095000, C564S096000, C564S097000, C564S098000, C564S099000, C560S010000, C548S145000, C548S186000, C548S213000, C548S266200, C548S269400, C548S302400, C548S315100, C548S323500, C548S346100, C548S538000, C548S569000, C546S016000, C546S172000, C546S213000, C546S203000, C546S232000, C546S269400, C546S280100, C546S285000, C544S380000, C544S133000, C544S146000, C544S
Reexamination Certificate
active
10239233
ABSTRACT:
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
REFERENCES:
patent: 3406184 (1968-10-01), Raasch
patent: 3715362 (1973-02-01), Dominianni
patent: 5168101 (1992-12-01), Arai et al.
patent: 5663417 (1997-09-01), Hamanaka et al.
patent: 5703129 (1997-12-01), Felsenstein et al.
patent: 5994398 (1999-11-01), John et al.
patent: 6172113 (2001-01-01), Ohtani et al.
patent: 6559162 (2003-05-01), Bjorsne et al.
patent: 6610734 (2003-08-01), Kreft et al.
patent: 6713650 (2004-03-01), Ibrahim et al.
patent: 6852761 (2005-02-01), South et al.
patent: 7138400 (2006-11-01), Collins et al.
patent: 7144910 (2006-12-01), Madin et al.
patent: 7183303 (2007-02-01), Castro Pineiro et al.
patent: 7205434 (2007-04-01), Hannam et al.
patent: 2004/0006050 (2004-01-01), Kreft et al.
patent: 2005/0245573 (2005-11-01), Neitzel et al.
patent: WO 98/38156 (1998-09-01), None
Solvolysis of 7-anti-bromo-2-exo-benzensulfonamidobicyclo(2.2.1)heptane. An example of solvolytic ring opening. Zalkow et al., Journal of the American Chemical Society, 1964, vol. 86(19), pp. 4208-4209.
The structure and reactions of the 1:1 adduct of benzenesulfonyl azide and bicyclo(2.2.1)heptene. Franz et al., Research Dept. Organic Chemical Division, Monsanto Co, 1963, vol. 29, pp. 2922-2927.
Bridged ring compounds. XIII. The reaction of N,N-dibromobenzenesulfonamide with bicyclo(2.2.1)heptene, bicyclo(2.2.2)octene, and endo-bicyclo(2.2.1)-5-heptene-2,3-dicarboxylic anhydride. Oehschlager et al., Department of Chem, Oklahoma, 1965.
Charles Glabe, Science 314, 602-603 (Oct. 27, 2006).
Zalkow, Tet. Letters 26(10) 2149 (1975).
J. E. Franz, et al.:Journal of Organic Chemistry, vol. 29, No. 10, Oct. 1964, pp. 2922-2927.
R. Huisgen, et al.:Chemische Berichte, vol. 98, No. 12, Dec. 1965, pp. 3992-4013.
S. Itsuno, et al.:Journal of the Chemical Society, Perkin Transactions 1, No. 10, Jul. 15, 1999 pp. 2011-2016.
M. Narisada, et al.:Journal of Medicinal Chemistry, vol. 31, No. 9, Sep. 1988, pp. 1847-1854.
G. M. Rishton, et al.:Journal of Medicinal Chemistry, vol. 43, No. 12, May 23, 2000, pp. 2297-2299.
K. B. Sharpless, et al.:Journal of Organic Chemistry, vol. 41, No. 1, Jan. 9, 1976, pp. 176-177.
Y. Yamaguchi, et al.:Xenobiotica, vol. 26, No. 6, Jun. 1996, pp. 613-626.
L. H. Zalkow, et al.:Journal of the American Chemical Society, vo. 86, No. 19, Oct. 5, 1964.
L. H. Zalkow, et al.:Journal of Organic Chemistry, vol. 28, No. 12, Dec. 1963, pp. 3303-3309.
Belanger Patrice Charles
Collins Ian James
Hannam Joanne Claire
Harrison Timothy
Lewis Stephen John
Berch Mark L
Krovatin William
Merck Frosst Canada & Co.
Merck Sharp & Dohme Ltd.
Todaro John C.
LandOfFree
Sulphonamido-substituted bridged bicycloalkyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulphonamido-substituted bridged bicycloalkyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulphonamido-substituted bridged bicycloalkyl derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3947833