Sulfur-containing naphthalimide derivatives

Details Sulfur-containing naphthalimide derivatives Sulfur-containing naphthalimide derivatives

2005-10-31

2009-06-02

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S066000, C546S067000, C514S280000, C514S285000, C514S287000

Reexamination Certificate

active

07541463

ABSTRACT:
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.

REFERENCES:
patent: 3888863 (1975-06-01), Troster
patent: 4254109 (1981-03-01), Sestanj
patent: 1391324 (1972-05-01), None
patent: 2238457 (1974-02-01), None
patent: 2353639 (1975-08-01), None
patent: 1 391 324 (1975-04-01), None
patent: 1562142 (1969-02-01), None
patent: 60-221403 (1985-11-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface. also p. 8 and 9.

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