Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-06
2006-06-06
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S354000, C544S249000
Reexamination Certificate
active
07056937
ABSTRACT:
Disclosed are 1-sulfonylquioxalone acetamides and derivatives thereof. The compounds are exemplified by compounds of the formula:Such compounds, derivatives and related compounds are useful as bradykinin antagonists.
REFERENCES:
patent: 3635971 (1972-01-01), Yellin et al.
patent: 3654275 (1972-04-01), McManus
patent: 5968951 (1999-10-01), Dodey et al.
patent: 6211196 (2001-04-01), Heitsch et al.
patent: 6369057 (2002-04-01), Billhardt et al.
patent: 43 41 663 (1993-12-01), None
patent: 0 622 361 (1994-11-01), None
patent: 1 188 755 (2002-03-01), None
patent: 03/007958 (2003-01-01), None
Romanenko et al, “Condensed and bound quinoxalines. IV. New pathway to acrylamides of (1,2-dihydro-2-oxo-3-quinoxalinyl) acetic acid” Khimiya Geterotsiklicheskikh Soedinenii, vol. 2, pp. 264-266 (1973).
Scoffone et al, Gazzetta Chimica Italiana, vol. 87, pp. 354-365 (1957).
de la Llosa et al, Bulletin de la Societe Chimique de France, pp. 1621-1625 (1960).
Cunningham and Day, Journal of Organic Chemistry, vol. 38(6), pp. 1225-1227 (1973).
Wagh et al, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, vol. 21B(12), pp. 1071-1073 (1982).
Romanenko et al, “Condensed and bound quinoxalines. IV. New pathway to acrylamides of (1,2-dihydro-2-oxo-3-quinoxalinyl) acetic acid” Khimiya Geterotsiklicheskikh Soedinenii, vol. 2, pp. 264-266 (1973). English Translation.
S.B. Wagh, et al., “Reactions of Cyclic, Anhydrides: Part VII—Reductive Cyclisation of 2-Nitromaleanilates & 2-Nitrofumaranilates, a New Synthesis of 2-Oxo-1,2,3,4-tetrahydroquinoxalines”, Indian Journal of Chemistry, Section B: Organic, Incl. Medicinal, Publications and Informations Diectorate, New Delhi, IN, V21B, No. 12, 12-82, pp. 1071-1073.
Scoffone E. et al., “Indagini Sulla Struttura Delle Proteine”, Gazzetta Chimica Italiana, Societa Chimica Italiana, Rome, IT, V87, 1957, pp. 354-365.
Menke, et al., “Expression Cloning of a Human B1Bradykinin Receptor”, J. Biol. Chem., 269(34):21583-21586 (1994).
Hess, et al., “Cloning and Pharmacological Characterization of a Human Bradykinin (BK-2) Receptor”, Biochem Biophys. Res. Commun., 184:260-268 (1992).
Burch, et al., “Bradykinin Receptor Antagonists”, Med., 30:237-269 (1990).
Ammons, et al., “Effects of Intracardiac Bradykinin on T2-T5Medial Spinothalamic Cells”, The American Physiological Society, 0363-6119, R147-R152 (1985).
Costello, et al., “Suppression of Carageenan-Induced Hyperalgesia, Hyperthermia and Edema by a Bradykinin Antagonist”, European Journal of Pharmacology, 171:259-263 (1989).
Laneuville, et al., “Bradykinin Analogue Blocks Bradykinin-induced Inhibition of a Spinal Nociceptive Reflex in the Rat”, European Journal of Pharmacology, 137:281-285 (1987).
Steranka, et al., “Antinociceptive Effects of Bradykinin Antagonists”, European Journal of Pharmacology, 136:261-262 (1987).
Steranka , et al., “Bradykinin as a Pain Mediator: Receptors are Localized to Sensory Neurons, and Antagonists have Analgesic Actions”, Neurobiology, 85:3245-3249 (1988).
Whalley, et al., “The Effect of Kinin Agonists and Antagonists on the Pain Response of the Human Blister Base”, Naunyn Schmiederberg's Arch. Pharmacol., 336:652-655 (1987).
Back, et al., “Determination of Components of the Kallikrein-Kinin System in the Cerebrospinal Fluid of Patients with Various Diseases”, Res. Clin. Stud. Headaches, 3:219-226 (1972).
Ness, et al., “Visceral Pain: a Review of Experimental Studies”, Pain, 41:167-234 (1990).
Aasen, et al., “Plasma kallikrein Activity and Prekallikrein Levels during Endotoxin Shock in Dogs”, Eur. Surg. Res., 10:50-62(1978).
Aasen, et al., “Plasma Kallikrein-Kinin System in Septicemia”, Arch. Surg., 118:343-346 (1983).
Katori, et al., “Evidence for the Involvement of a Plasma Kallikrein-Kinin System in the Immediate Hypotension Produced by Endotoxin in Anaesthetized Rats”, Br. J. Pharmacol., 98:1383-1391 (1989).
Marceau, et al., “Pharmacology of Kinins: Their Relevance to Tissue Injury and Inflammation”, Gen. Pharmacol., 14:209-229 (1983).
Weipert, et al., “Attenuation of arterial blood pressure fall endotoxin shock in the rat using the competitive bradykinin antagonist Lys-Lys-[Hyp2, Thi5,8, DPhe7]-BK (B4148)”, Brit J. Pharm., 94:282-284 (1988).
Haberland, “The Role of Kininogenases, Kinin Formation and Kininogenase Inhibition in Post Traumatic Shock and Related Conditions”, Klinische Woochen-Schrift, 56:325-331 (1978).
Ellis, et al., “Inhibition of Bradykinin-and Kallikrein-Induced Cerebral Arteriolar Dilation by Specific Bradykinin Antagonist”, Stroke, 18:792-795 (1987).
Kamitani, et al., “Evidence for a Possible Role of the Brain Kallikrein-Kinin System in the Modulation of the Cerebral Circulation”, Circ. Res., 57:545-552 (1985).
Barnes, “Inflammatory Mediator Receptors and Asthma”, Am. Rev. Respir. Dis., 135:S26-S31 (1987).
Fuller, et al., “Bradykinin-Induced Bronchoconstriction in Humans”, Am. Rev. Respir. Dis., 135:176-180 (1987).
Jin, et al., “Inhibition of Bradykinin-Induced Bronchoconstriction in the Guinea-Pig by a Synthetic B2Receptor Antagonist”, Br. J. Pharmacol., 97:598-602 (1989).
Polosa, et al., “Contribution of Histamine and Prostanoids to Bronchoconstriction Provoked by Inhaled Bradykinin in Atopic Asthma”, Allergy, 45:174-182 (1990).
Baumgarten, et al., “Concentrations of Glandular Kallikrein in Human Nasal Secretions Increase During Experimentally induced Allergic Rhinitis”, J. Immunology, 137:1323-1328 (1986).
Proud, et al., “Nasal Provocation with Bradykinin Induces Symptoms of Rhinitis and a Sore Throat”, Am. Rev. Respir. Dis., 137:613-616 (1988).
Seabrook, et al., “Expression of B1and B2Bradykinin Receptor mRNA and Their Functional Roles in Sympathetic Ganglia and Sensory Dorsal Root Ganglia Neurons from Wild-type and B2Receptor Knockout Mice”, Neuropharmacology, 36(7):1009-17 (1997)..
Couture et al. “Kinin receptors in pain and inflammation”European Journal of Pharmacology429:161-176 (2001).
Ozturk, “Kinin Receptors and Their Antagonists as Novel Therapeutic Agents”Current Pharmaceutical Design7:135-161 (2001).
Howl and Payne Bradykinin receptors as a therapeutic targetExpert Opinion on Therapeutic Targets7(2):277-285 (2003).
Bartulis Sarah
Brogley Louis
Dappen Michael S.
Grant Francine S.
Hawkinson Jon E.
Elan Pharmaceuticals Inc.
Foley & Lardner LLP
Tucker Zachary C.
Wilson James O.
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