Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-06
1998-06-02
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142378, 514445, 514539, 514602, 514603, 514604, 514605, 544160, 546194, 546234, 549 65, 560 13, 564 80, 564 84, 564 86, 564 87, 564 89, 564 90, 564 91, 564 93, 564 94, 564 95, 564 98, 564 99, A61K 3138, A61K 3144, A61K 3118
Patent
active
057600643
ABSTRACT:
Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4599198 (1986-07-01), Hoover
Roberts et al., "Rational Design of Peptide-based Proteinase Inhibitors, "Science, 248, 358 (1990).
Erickson et al., "Design Activity, and 2.8A Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease, "Science, 527, (1990).
S.J. Fittkau, Prakt. Chem., 315, 1037 (1973).
Pauwles et al., "Rapid and automated tetrazolium-based colormetric assay for the detection of anti-HIV compounds, "J.Virol. Methods, 20, 309-321 (1988).
DeCrescenzo Gary A.
Freskos John N.
Getman Daniel
Mueller Richard A.
Talley John J.
G.D. Searle
O'Sullivan Peter
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