Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1999-04-27
2000-07-11
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564 99, C07D21162, A61K 3118, C07C31108
Patent
active
06087399&
ABSTRACT:
Compounds of formula I ##STR1## in which R(1) to R(8) and X have the meanings indicated in the specification, are useful for the production of medicaments having K.sup.+ channel-blocking action; in particular for the production of a medicament for the treatment or prophylaxis of stimulated gastric acid secretion; of ulcers of the stomach and of the intestinal region; of reflux esophagitis; of diarrhea; of all types of arrhythmias, including ventricular and supraventricular arrhythmias; and of reentry arrhythmias and for the prophylaxis of sudden heart death as a result of ventricular fibrillation.
REFERENCES:
Paul D. Leeson et al., "4-Amido-2-carboxytetrahydroquinolines. Structure-Activity Relationships for Antagonism at the Glycine Site of the NMDA Receptor," J. Med. Chem, vol. 35, pp. 1954-1968 (1992).
Thomas J. Colatsky et al., "Channel Specificity in Antiarrhythmic Drug Action: Mechanism of Potassium Channel Block and Its Role in Suppressing and Aggravating Cardiac Arrhythmias," Circulation, vol. 82, No. 6, pp. 2235-2242 (Dec. 1990).
Andreas E. Busch et al., "The Novel Class III Antiarrhythmics NE-10064 and NE-10133 Inhibit I.sub.SK Channels Expressed in Xenopus Oocytes and I.sub.KS in Guinea Pig Cardiac Myoctyes," Biochemical and Biophysical Research Communications, vol. 202, No. 1, pp. 265-270 (Jul. 15, 1994).
Brendel Joachim
Gerlach Uwe
Lang Hans Jochen
Weidmann Klaus
Davis Zinna Northington
Hoechst Aktiengesellschaft
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