Substituted thiophenes with antibacterial activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S313000, C546S153000, C546S159000

Reexamination Certificate

active

07030137

ABSTRACT:
Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.

REFERENCES:
patent: 6320051 (2001-11-01), Berge et al.
patent: 0 785 268 (1997-07-01), None
patent: WO 00/71522 (2000-11-01), None
patent: WO 00/71524 (2000-11-01), None
Fleischmann et al. (1995) Science 269:496-512.
Gutschow (1996) J. Het. Chem. 33:355-360.
Lespagnol et al. (1968) Ann Pharm Fr. 26(3):207-14 (and abstract in English).
Jarvest et al. (2002) J. Med. Chem. 45:1959.

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