Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2011-02-22
2011-02-22
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
active
07893260
ABSTRACT:
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3. Suitable compounds include but are not limited to, for example, substituted quinazolin-4-ones of formula I.
REFERENCES:
patent: 4183931 (1980-01-01), Wolfe et al.
patent: 5196427 (1993-03-01), Yu et al.
patent: 5869665 (1999-02-01), Padia
patent: 5892114 (1999-04-01), Goldmann et al.
patent: 5962457 (1999-10-01), Chenard et al.
patent: 6060479 (2000-05-01), Chenard et al.
patent: 6136812 (2000-10-01), Chenard et al.
patent: 6191157 (2001-02-01), Goldmann et al.
patent: 6303615 (2001-10-01), Elliott et al.
patent: 6323208 (2001-11-01), Chenard et al.
patent: 6329360 (2001-12-01), Goldmann et al.
patent: 6380204 (2002-04-01), Chenard et al.
patent: 6627755 (2003-09-01), Chenard et al.
patent: 6921764 (2005-07-01), Chenard et al.
patent: 7053216 (2006-05-01), Sun et al.
patent: 2002/0156253 (2002-10-01), Curtis et al.
patent: 2003/0027164 (2003-02-01), Gaughan et al.
patent: 2003/0027232 (2003-02-01), Davis et al.
patent: 2003/0157633 (2003-08-01), Bevan et al.
patent: 2003/0219806 (2003-11-01), Glucksmann et al.
patent: 2004/0009537 (2004-01-01), Roos et al.
patent: 2004/0110777 (2004-06-01), Annis et al.
patent: 2005/0203159 (2005-09-01), Zelle et al.
patent: 2006/0052345 (2006-03-01), Shcherbakova et al.
patent: 2006/0270688 (2006-11-01), Chong et al.
patent: 2007/0213321 (2007-09-01), Chong et al.
patent: 2008/0146611 (2008-06-01), Moran et al.
patent: 0 807 633 (1997-11-01), None
patent: 0934934 (1999-08-01), None
patent: WO-97/43276 (1997-11-01), None
patent: WO-98/38173 (1998-09-01), None
patent: WO-98/38187 (1998-09-01), None
patent: WO-01/19800 (2001-03-01), None
patent: WO-02/101045 (2002-12-01), None
patent: WO-03/043961 (2003-05-01), None
patent: WO-03/106435 (2003-12-01), None
patent: WO-2004/041755 (2004-05-01), None
patent: WO-2005/049613 (2005-06-01), None
patent: WO-2005/120511 (2005-12-01), None
patent: WO-2006/047516 (2006-05-01), None
patent: WO-2006/120481 (2006-11-01), None
patent: WO-2006/122200 (2006-11-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2005, Preface.
Wolff, Manfred E., Ed. Burger's Medicinal Chemistry and Drug Discovery—Fifth Edition, New York: John Wiley & Sons, 1996, vol. 1, pp. 975-976.
Ramsey, et al. Annu. Rev. Physiol., 68, 2006, pp. 619-647.
Vippagunta, et al. Advanced Drug Delivery Reviews, 48, 2001, p. 18.
Hackam, et al. JAMA, 296(14), 2006, 1731-1732.
U.S. Appl. No. 11/920,184, filed Nov. 9, 2007, Chong et al.
U.S. Appl. No. 12/084,610, filed May 9, 2008, Chong et al.
U.S. Appl. No. 12/152,131, filed May 12, 2008, Chong et al.
Daidone, G., et al., “Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives,” Arch. Pharm. Pharm. Med. Chem., 332:50-54 (1999).
Naithani, P.K., et al., “2,3-Disubstituted quinazolinones and their antiparkinsonian activity,” Indian Journal of Chemistry Section B, 28B:745-750 (1989).
Pandey, V.K., et al., “Quinazolyl-thiazoles as CNS acting agents,” Acta Pharm., 46:51-59 (1996).
Park, H., et al., “A novel class of Hsp90 inhibitors isolated by structure-based virtual screening,” Bioorganic & Medicinal Chemistry Letters, 17:6345-6349 (2007).
Raffa, D., et al., “Synthesis and antileukemic activity of new 3-(1-phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones,” II Farmaco, 59:215-221 (2004).
Raffa, D., et al., “Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones,” II Farmaco, 59:451-455 (2004).
Saleh, M.A., et al., “Synthesis and Antiviral Evaluation of Some New Glycosylthioureas Containing a Quinazolinone Nucleus,” Nucleosides, Nucleotides & Nucleic Acids, 21(1):93-106 (2002).
Saleh, M.A., et al., “Synthesis and Biological Activities of Some New 3H-Quinazolin-4-One Derivatives Derived from 3-Phenylamino-2-Thioxo-3H-Quinazolin-4-One,” Phosphorus, Sulfur, and Silicon, 179:411-426 (2004).
Shishoo, C.J., et al., “Synthesis and pharmacological evaluation of some novel 5-aryl-6-arylamino-1-phenylpyrazolo[3,4-d] pyrimidin-4(5H)-ones as analgesic and anti-inflammatory agents,” Indian Journal of Chemistry Section B, 38B:684-695 (1999).
Welch, W.M., et al., “Atropisomeric Quinazolin-4-one Derivatives are Potent Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists,” Bioorganic & Medicinal Chemistry Letters, 11(2):177-181 (2001).
Chenard et al., “Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure-Activity Relationship of the C-2 Side Chain Tether,” J. Med. Chem. 44: 1710-1717 (2001).
Badr et al., “Studies on the synthesis of 2,3-disubstituted 4(3H)quinazolinone.” Egyptian Journal of Chemistry, 19(2):341-346(1976).
Burnstock, G., and Williams, M., “P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential,” J. Pharmacol. Exp. Ther. 295(3):862-869(2000).
Burnstock, Geoffrey., “Pathophysiology and Therapeutic Potential of Purinergic Signaling,” Pharmacol. Rev. 58(1):58-86(2006).
Chung et al., “Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3,” J. of Biological Chemistry 280: 15928-15941(2005).
Clapham et al., “The TRP Ion Channel Family,” Nature Reviews, 2: 387-396(2001).
Clapham, David E., “Hot and Cold TRP Ion Channels,” Science, 295: 2228-2229(2002).
Clapham, David E., “TRP channels as cellular sensors,” Nature, 426: 517-524(2003).
Felder et al., “Synthesis of 4(3H)-pteridinones.” J. Med. Chem., 15(2):210-211(1972).
Foresta et al., “Extracellular ATP is a Trigger for the Acrosome Reaction in Human Spermatozoa,” J. of Biological Chem., 267(27):19443-19447(1992).
Gopinath et al., “Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain,” BMC Womens Health 5:2(2005).
Krezschmar, E., “Derivatives of 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine.” Pharmazie, 35(5-6):253-256(1980).
Kumar et al., “Synthesis and hypotensive activity of trisubstituted quinazolinones.” European J. Med. Chem., 20(1):95-96(1985).
Leszkovszky et al., “The pharmacology of quinazolone derivatives.” Acta Physiol. Akad. Sci. Hung., 27(1):81-90(1965).
Moqrich et al, “Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin,” Science 307(5714): 1468-1472(2005).
Moran et al., “TRP Ion Channels In the Nervous System,” Current Opinion in Neurobiology, 14: 362-369(2004).
Nikolova et al., “Characteristics of the analgesic effect of a quinazolone derivative.” Farmatsiya (Sofia, Bulgaria), 27(1):53-59(1977). (English abstract provided on p. 59.).
Nikolova et al., “Screening of new synthesized compounds for analgesic effect according to knoll's method.” Farmatsiya (Sofia, Bulgaria), 25(4):47-53(1975). (English abstract provided on pp. 52-53.).
Peier et al., “A Heat-Sensitive TRP Channel Expressed in Keratinocytes,” Science, 296: 2046-2049(2002).
Ramana et al., “Mass spectrometer as a probe in the synthesis of 2-substituted-3-phenyl-4 (3H)-quinazolinones.” Indian J. of Heterocyclic Chem., 9(3): 173-180(2000).
Ramsey et al., “An Introduction to TRP Channels,” Annual Rev. Physiology, 68: 619-647(2006).
Smith et al., “TRPV3 is a temperature-sensitive vallinoid receptor-like protein,” Nature, 418: 186-190 (2002).
Stefanova, D., “Central depressive effects of M50.” Farmatsiya (Sofia, Bulgaria), 24(2)
Chong Jayhong A.
Fanger Christopher
Larsen Glenn R.
Lumma, Jr. William C.
Moran Magdalene M.
Foley & Hoag LLP
Gordon Dana M.
Hydra Biosciences, Inc.
Willis Douglas M
Wilson James O
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