Substituted pyrrolo[2,3-2]pyrimidines as protein kinase...

Details Substituted pyrrolo[2,3-2]pyrimidines as protein kinase... Substituted pyrrolo[2,3-2]pyrimidines as protein kinase...

2011-06-28

2011-06-28

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S280000, C544S279000, C514S264100

Reexamination Certificate

active

07968557

ABSTRACT:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.

REFERENCES:
patent: 2004/0224964 (2004-11-01), O'Yang et al.
patent: 194820 (1967-04-01), None
patent: WO03/074530 (2003-09-01), None
patent: WO2005/107760 (2005-11-01), None
patent: WO2006/074985 (2006-07-01), None
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
Vippagunta, S.R., “Advanced Drug Delivery Reviews,” 2001, 48, pp. 3-26.
Ha-Soon Choi et al., Design and Synthesis of 7H-Pyrrolo[2,3-d]pyrimidines as Focal Adhesion Kinase Inhibitors. Part 1, Bioorganic & Medical Chemistry Letters, Feb. 3, 2006, 2173-2176, Elsevier Ltd.
Ha-Soon Choi et al., Design and Synthesis of 7H-Pyrrolo[2,3-d]pyrimidines as Focal Adhesion Kinase Inhibitors. Part 2, Bioorganic & Medical Chemistry Letters, Mar. 9, 2006, 2689-2692, Elsevier Ltd.
Yakhontov et al; “Azaindole Derivatives XXVI. The Formation of 5,7-diazaindoline derivatives by the reaction of 4-chloro-5-(beta-chloroethyl)pyrimidines with secondary amines”; Khimiya Geterotsiklicheskikh Soedinenii 1:145-148 (1969)—English translation of abstract and partial experimentals provided.

Affiliated with

Also associated with

Rating

Substituted pyrrolo[2,3-2]pyrimidines as protein kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted pyrrolo[2,3-2]pyrimidines as protein kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyrrolo[2,3-2]pyrimidines as protein kinase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2671488