Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-01-22
2011-11-15
Kosar, Andrew D (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
08058285
ABSTRACT:
The invention relates to compounds of general formula (I); 1a, 1 b, 1 c and 1 d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or physiologically compatible salts thereof which can be produced therefrom and/or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and/or TNFα-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.
REFERENCES:
patent: 1 277 738 (2001-04-01), None
patent: 1 277 738 (2003-01-01), None
patent: 1 323 719 (2003-07-01), None
Vieweg, H., et al., Synthesis of 2,3-dihydroimidazo[1,2-c]- and 3,4-dihydro-2H-pyrimido[1,2- c]pyrido[3′,2′ :4,5]thieno[2,3-e]pyrimidines via 4-(w-hydroxyalkylamino) derivatives of pyridothienopyrimidines. Part 35. Polycyclic azines with heteroatoms in 1- and 3-position, Pharmazie 47(10), 751-4 (1992).
Michael, J. M., New pyrido [3,2:4,5] thieno [3,2-D] pyrimidines of possible antimicrobial activity, Al-Azhar Bulletin of Science, 3(2), 767-75 (1992).
Quintela, Jose M., et al., Synthesis and antiallergic activity of pyridothienopyrimidines, Bioorganic & Medicinal Chemistry 6(10), 1911-1925 (1998).
Tornetta, Benedetto, et al., Synthesis and spectral behavior of pyridothienoisothiazole and pyridothienopyrimidine derivatives, Gazzetta Chimica Italiana, 108(1-2), 57-62 (1978).
Peinador, et al., A Convenient Synthesis for Some New Pyrido[3′,2′:4:5]thieno-[3,2-d]pyrimidine Derivatives with Potential Biological Activity, J. Heterocyclic Chem., 29, 1693 (1992).
Wolff, Manfred E., Burger's Medicinal Chemistry and Drug Discovery, Fifth Ed., vol. 1: Principles and Practice, John Wiley & Sons, 1995, 975.
Banker, Gilbert S. et al., Modem Pharmaceutics, Marcel Dekker, New York, 1996.
Doherty, Phosphodiesterase 4 Inhibitors as Novel Anti-inflammatory Agents. Curr. Opin. Chem. Biol., 3, 466-473 (1999).
Essayan, Cyclic Nucleotide Phosphodiesterase (PDE) Inhibitors and Immunomodulation, Biochem. Pharmacol., 57, 565-573 (1999).
Dal Piaz, et al., Phosphodiesterase 4 Inhibitors, Structurally Unrelated to Rolipram, as Promising Agents for Treatment of Asthma and Other Pathologies, Eur. J. Med. Chem., 35, 463-480 (2000).
Quintela, Jose M., et al., Synthesis and antiallergic activity of pyridothienopyrimidines, Bioorganic & Medicinal Chemistry 6(10), 1911-1925 (1998).
José M. Quintela et al.: “Synthesis and Antiallergic Activity of Pyridothienopyrimidines” Bioorg. Med. Chem, Bd. 6, 1998, Seiten 1911-1925, XP002310819 Tabelle 1.
Peinador C et al: “A Convenient Synthesis for Some Pyrido 3′, 2′ :4,5!thieno 3,2-d!pyrimi dine Derivatives with Potential Biological Activity” Journal of Heterocyclic Chemistry, Heterocorporation. Provo, US, Bd. 29, Dec. 1992, Seiten 1693-1702, XP002244954 ISSN: 0022-152X Verbindungen 8-18.
G. Wagner et al.: “Synthese von acylierten 4-Hydrazino-pyrido 3′,2′ :4,5!thieno 3,2-d! pyrimidinen und tetracyclischen Verbindungen gleicher tricyclischer Grundstruktur und einem am Pyrimidinring annelierten Heterocyclus” Pharmazie, Bd. 48, 1993, Seiten 20-23, XP002310820 Verbindung 2b.
Vieweg H. et al.: “Synthese von 2,3-Dihydro-imidazo 1,2-c!-und 3,4-Dihydro-2H-pyrimido 1,2-c!-annelierten Pyrido 3′ ,2′ :4,5!thieno 2,3-e! pyrimidinen aus 4-(omega-Hydroxyalkylamino)-Verbindungen von Pyridothienopyrimidinen” Pharmazie, Bd. 47, 1992, Seiten 751-754, XP002310821 Verbindung D2,D3,D5.
Database Chemcats Chemincal Abstracts Service, Columbus, Ohio, US; XP002352717 Order No. PHAR027215, PHAR058716 & “Synthetic and Natural Compounds Product List” (Mar. 17, 2004), Pharmeks Ltd., Chuksin Tupik 4, of. 15, Moscow, 125206, Russia.
Database Chemcats Chemical Abstracts Service, Columbus, Ohio, US; XP002352718 Order No. STOCK4S-39856, STOCK4S-17994, STOCK4S-31384 & “Interchim Intermediates” Jan. 18, 2005, Interchim, 211 Bis AV JF Kennedy, BP 1140, Montlucon, 03103, France.
Database Chemcats, Chemical Abstracts Service, Columbus, Ohio, US; XP002352719 Order No. PHAR094558 & “Ambinter Stock Screening Collection” Jul. 3, 2005, Ambinter, 50 Avenue De Versailles, Paris, F-75016, France.
Young Chul Park et al., “Wortmannin, a Specific Inhibitor of Phosphatidylinositol-3-kinase, Enhances LPS-Induced NO Production from Murine Peritoneal Macrophages” Article No. RC977722, pp. 692-696 (1997).
Gernot Schabbauer et al., “PI3K-Akt Pathway Suppresses Coagulation and Inflammation in Endotoxemic Mice” Oct. 2004, pp. 1963-1969.
Eun-Kyoung Choi et al., “Enhancement of cytokine-mediated NF-κb activation by phosphatidylinositol 3-kinase inhibitors in monocytic cells” pp. 908-915 (2006).
Daghish Mohammed
Heinicke Jochen
Krödel Andreas
Leistner Siegfried
Ludwig Alexander
Kiselgof Eugenia
Kosar Andrew D
Kowalski Thomas J.
Leeser Erich A
The Medicines Company (Leipzig) GmbH
LandOfFree
Substituted pyrido [3′, 2′: 4, 5] thieno [3,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted pyrido [3′, 2′: 4, 5] thieno [3,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyrido [3′, 2′: 4, 5] thieno [3,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4282726