Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-29
2010-11-09
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S254060, C514S322000, C548S360100
Reexamination Certificate
active
07829559
ABSTRACT:
The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula (I) and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.
REFERENCES:
patent: 4734429 (1988-03-01), Le Tourneau et al.
patent: 7282499 (2007-10-01), Arjona et al.
patent: 0 276 834 (1988-08-01), None
patent: 0 414 289 (1991-02-01), None
patent: 0 431 943 (1991-06-01), None
patent: 0 445 974 (1991-09-01), None
patent: 0 518 805 (1992-12-01), None
patent: 57-165369 (1982-10-01), None
patent: WO 91/09594 (1991-07-01), None
patent: WO96/04287 (1996-02-01), None
patent: WO02/102387 (2002-12-01), None
patent: WO2006/021463 (2006-03-01), None
Vippagunta et al, “Crystalline Solids”, Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
Gavezzotti, “Are Crystal Structures Predictable?”, Accounts of Chemical Research, vol. 27, pp. 309-314 (1994).
International Search Report for International Application No. PCT/EP2005/009377, mailed Oct. 26, 2005.
Dehaven-Hudkins, D., et al., “Characterization of the binding of [3H](+)-pentazocine to σ recognition sites in guinea pig brain,”Eur. J. Pharmacol., vol. 227: 371-378, 1992.
Hanner, M., et al., “Purification, molecular cloning, and expression of the mammalian sigma1-binding site,” Proc. Natl. Acad. Sci., vol. 93: 8072-8077, Jul. 1996.
Langa, F., et al., “Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice,” European Journal of Neuroscience, vol. 18: 2188-2196, 2003.
Lowry, O.H., et al., “Protein Measurement With The Folin Phenol Reagent,” J. Biol. Chem., pp. 265-275, 1951.
Mosti, L., et al., “Acetic Acids Bearing the 1-Phenyl-1H-Indazole Nucleus With Analgesic and Antiinflammatory Activity,” IL Farmaco, vol. 43: 763-774, Oct. 1988.
Peet, N.P., et al, “Synthesis Of Angular Benzodipyrazoles And Related Systems,” Heterocycles, vol. 32, No. 1: 41-72, 1991.
Quirion, R. et al., “A proposal for the classification of sigma binding sites,” Trends Pharmacol. Sci., vol. 13: 85-86, 1992.
Radesca, L., et al., “Synthesis and Receptor Binding of Enantiomeric N-Substituted cis-N-[2-(3,4-Dichlorophenyl)ethyl]-2-(1-pyrrolidinyl) cyclohexylamines as High-Affinity σ Receptor Ligands,” J. Med. Chem., vol. 34: 3058-3065, 1991.
Schenone, P., et al., “Reaction of 2-Dimethylaminomethylene-1, 3-diones with Dinucleophiles. I. Synthesis of 1,5-Disubstituted 4-Acylpyrazoles,” Heterocyclic Chem., vol. 19: 1355-1361, 1982.
Snyder, S.H., et al., “Receptor Mechanisms in Antipsychotic Drug Action: Focus on Sigma Receptors,” Journal of Neuropsychiatry, vol. 1: 7-15, 1989.
Trehan, I. R., et al., “Synthesis of 2,3,13-Triaza-18-nor-I7-oxo-3-phenyl-A-nor-estra-I,5(10), 9(II)-triene & 2,3,13-Triaza-7, 7-dimethy1-18-nor-17-oxo-3-pheny1-A-nor-estra-I,5(10), 9(II)-triene,” Indian Journal of Chemistry, vol. 19B: 243-245, Apr. 1980.
Walker, J.M., et al., “Sigma Receptors: Biology and Function,” Pharmacological Reviews, vol. 42: 355-402, 1990.
European Patent Office, European Search Report for European Application 04077422.6, dated Jan. 21, 2005.
Arjona Jordi Corbera
Cuberes-Altisent Maria Rosa
Holenz Joerg
Martínez-Olmo Daniel
Vaño-Domenech David
Laboratorios Del Dr. Esteve, S.A.
Locke Lord Bissell & Liddell LLP
Rodriguez-Garcia Valerie
Saeed Kamal A
Schurter Brandon T.
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