Substituted pyrazine and its salts, compositions containing them

Details Substituted pyrazine and its salts, compositions containing them Substituted pyrazine and its salts, compositions containing them

1993-03-10

1995-01-24

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544409, 546137, C07D45302, A61K 31495

Patent

active

053844084

ABSTRACT:
3(R)-[2-(6-trifluoromethylpyrazin)yl]-1-azabicyclo[2.2.2]octane and its salts, and pharmaceutical formulations thereof are useful in medicine. In particular, they are useful for the treatment of neurological and mental illnesses whose clinical manifestations are due to cholinergic deficiency, and for lowering intraocular pressure. The compound may be prepared by dehydroxylating or decarboxylating the corresponding 3-hydroxy- or carboxy-quinuclidine analogue.

REFERENCES:
patent: 5073557 (1991-12-01), Baker et al.
Basic and Clinical Pharmacology by Bertram G. Katzung, (4th. Ed.) (1989), pp. 70-71, 78-79.
Drugs and Ther. Bulletin (Commerce Association of Britain) 1989, vol. 21, p. 85.
Heel et al Drugs, 1979, vol. 17, 38.
Br. J. Pharmac., vol. 92, pp. 817-826 (1987), by Newberry, et al.
Br. J. Pharmac., vol. 101, pp. 575-580 (1990), by Freedman, et al.
The New England Journal of Medicine, Oct. 12, 1989, pp. 1022-1029--"Muscarinic Receptor Subtypes" by R. K. Goyal.
J. of Ocular Pharmacology, (1990) vol. 6, No. 1, pp. 1-7, "Prostagandins Mediate . . . " by V. J. Lotti et al.
Br. J. Pharmacol. (1992) 107, 494-501, "L-689,660, a novel cholinominetic . . . " by R. J. Hargreaves et al.
"Glaxo Guide to Pharmacology" Mar. 1993, pp. 8, 14, published by Pharmacology Division Staff, Glaxo Group Research Ltd.
Med. Chem. Res. (1993) 3: 171-177, "L-696,986: A Functionally selective . . . " by G. A. Showell et al.
J. Med. Chem. 1987 30, pp. 969-975 "Synthesis and Characterization . . . " by J. Saunders et al.

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