Substituted piperidines therapeutic process and compositions

Details Substituted piperidines therapeutic process and compositions Substituted piperidines therapeutic process and compositions

1979-11-28

1981-12-01

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424267, A61K 31445, A61K 31455

Patent

active

RE0308110

ABSTRACT:
The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.

REFERENCES:
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patent: 3192213 (1965-01-01), Krapcho
patent: 3789072 (1974-01-01), Bernstein
patent: 3931195 (1976-01-01), Dykstra et al.
Lawson, J. Pharm. Exp. Therap., 160, pp. 21-31 (1968).
Krapcho et al., J. Med. Chem., 6, p. 219 (1963).
Krapcho et al., J. Med. Chem., 7, pp. 376-377 (1964).
Krapcho et al., J. Med. Chem., 9, pp. 809-812 (1966).
Krapcho et al., J. Med. Chem., 12, pp. 164-166 (1969).
Phillips, J. Am. Chem. Soc., 72, pp. 1850-1852 (1950).

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