Substituted piperazines for treatment of non-insulin dependent d

Details Substituted piperazines for treatment of non-insulin dependent d Substituted piperazines for treatment of non-insulin dependent d

1994-07-21

1996-02-20

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544295, 544369, 544370, 544374, 5142288, A61K 31415, C07D40104, C07D41306, C07D41304

Patent

active

054929121

ABSTRACT:
A compound selected from those of formula (I): ##STR1## in which A represents ##STR2## X represents N-R.sub.4 or oxygen, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, n and m are as defined in the description, useful in improving glucose tolerance in the treatment of non-insulin-dependent diabetes.

REFERENCES:
patent: 2562036 (1951-07-01), Hultquist et al.
patent: 3557135 (1971-01-01), Marchetti
Nathani, P., Indian Journal of Chemistry, "2,3-Disubstituted Quinazolinones and Their Antiparkinsonian Activity", vol. 28B (1989) pp. 745-750.
Street, L., J. Med. Chem., "Synthesis and Biological Activity of 1,2,4-Oxadiazole Derivatives: Highly Potent and Efficacious Agonists for Cortical Muscarinic Receptors", 33, (1990), 2690-2697.
Kuzmierkiewicz, W., Scientia Pharmaceutica, "3,5-Disubstituted Derivatives of 1,2,4-Triazole Synthesis and Hypotensive Activity", 53, (1985) 133-138.

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