Substituted phenyl compounds and derivatives thereof that modula

Details Substituted phenyl compounds and derivatives thereof that modula Substituted phenyl compounds and derivatives thereof that modula

1996-01-23

1999-11-02

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514381, 514784, 544335, 548250, 548253, 562405, 562462, 562473, 562474, 206461, 206828, A61K 3103, A61K 31505, C07C 6306, C07D23902

Patent

active

059771178

ABSTRACT:
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (I): ##STR1## where X and Y are selected from groups that include O, S, and NH; and Ar.sup.1, Ar.sup.2 and Ar.sup.3 are independently selected from substituted or unsubstituted groups that include 5 to 6 membered aryl groups and heteraryl groups that contain one or two heteroatom(s). The methods are effected by contacting endothelin receptors with one or more of the compounds or with compositions containing one or more of the compounds prior to, simultaneously with, or subsequent to contacting the receptors with an endothelin peptide.

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