Substituted oxindole derivatives as tyrosine kinase inhibitors

Details Substituted oxindole derivatives as tyrosine kinase inhibitors Substituted oxindole derivatives as tyrosine kinase inhibitors

2006-07-04

2006-07-04

Shameem, Golam M M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S277700, C548S138000, C548S483000, C548S484000, C514S363000, C514S418000

Reexamination Certificate

active

07071217

ABSTRACT:
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis, In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

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